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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“It was also found that arginine incorporation by the cytoplasmic protein-synthesizing system is increased in vivo after chronic ethanol feeding.”
Effects of chronic ethanol consumption on the rate of rat liver mitochondrial protein turnover and synthesis.“Furthermore, 10 mM Arg significantly attenuated the cytotoxicity induced by 100 mM ethanol treatment (P < 0.0001).”
“Intriguingly, Ingenuity Pathway Analysis (IPA) based pathway analysis suggested that the three ethanol degradation pathways were significantly altered between Ctrl and + Arg.”
“This study is the first time to reveal that Arg activates ethanol degradation pathways in HepG2 cells.”
“However an influence of alcohol on arginine metabolism may help explain the so called 'French paradox'.”
“In addition alcohol apparently potentiates insulin secretion stimulated by glucose, arginine and tolbutamide [S] .”
“The growth-hormone response to an arginine stimulus was lower after alcohol than after saline in all subjects.”
“In 3 normal subjects and in 4 acromegalic patients pretreatment with an alcohol infusion for 4 hours at a constant rate reduced the GH response to Arginine , when comparison was made with pretreatment with saline.”
“The antidepressant-like effect of ethanol (2.5 g/kg) was reversed by co-administration of N-methyl-D-aspartate (NMDA, 75 mg/kg), L-arginine (750 mg/kg), or sildenafil (5 mg/kg).”
Antidepressant-like effect of ethanol in mice forced swimming test is mediated via inhibition of NMDA/nitric oxide/cGMP signaling pathway.“with endogenous agmatine enhancers like l-arginine (80 μg/mouse) or arcaine (50 μg/mouse) and aminoguanidine (25 μg/mouse) restrained the development as well as expression of sensitization to EtOH.”
“Conversely, arginine decreased the urine levels of acetamide, β-glucose, cirtulline, ethanol , glycine, isobutyrate, lactate, malonate, methymalonate, N-acetylglutamate, N-methylnicotinamide, and propionate.”
“ Ethanol amnesia was also prevented by pre-test administration of L-arginine (1.2 μg/mouse, intra-CA1), a NO precursor.”
“Interestingly, an ineffective dose of nicotine (0.2 μg/mouse) in combination with a low dose of L-arginine (0.8 μg/mouse) synergistically improved memory performance impaired by ethanol given before training.”
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