Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Arachidonic Acid

supplement:

Ethanol

supplement:

Arachidonic Acid

Research Papers that Mention the Interaction

Arachidonic acid induced ERK1/2 phosphorylation and nuclear translocation of early growth response-1 (Egr1), and ethanol synergized with arachidonic acid to promote this effect.
American journal of physiology. Gastrointestinal and liver physiology  •  2012  |  View Paper
These results indicate that ethanol acutely inhibits muscarinic receptor signaling through the arachidonic acid pathway in a noncompetitive manner, but chronically enhances muscarinic signaling through the same pathway.
Alcoholism, clinical and experimental research  •  1998  |  View Paper
Arachidonic acid evoked irreversible platelet aggregation in all four preparations; this was significantly inhibited by the high dose ethanol in human and rat PRP, but not whole blood.
Thrombosis research  •  1995  |  View Paper
Alcohol 4 …) arachidonic acid induced platelet aggregation of human platelet-rich plasma (I50 = 0.65 +/- 0.1 microM); (b) 11,9-epoxymethano-PGH2 induced contraction of guinea … rat aorta (pA2 = 8.1 +/- 0.2); and (c) arachidonic acid induced bronchoconstriction in the anesthetized guinea pig (1 mg/kg iv).
Journal of medicinal chemistry  •  1990  |  View Paper
In other animal models, alcohol has been reported to alter blood platelet metabolism of arachidonic acid , to suppress the enzymatic degradation of PGs, and to alter the response of the adenyl cyclase system to several hormones including PGs of the "E" series.
This chapter reviews evidence for both direct and indirect biochemical interactions between ethanol and the metabolism of arachidonic acid and several related compounds.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism  •  1985  |  View Paper
Previous research has demonstrated that prolonged exposure to ethanol results in alterations in the oxidative metabolism of arachidonic acid including lowered membrane levels of arachidonate, increased arachidonate peroxidation, and increased oxidation of arachidonate to prostaglandin E2.
Biochemical medicine  •  1979  |  View Paper
Arachidonic acid altered cell proliferation and was cytotoxic mostly to cells engineered to overexpress CYP2E1 but both effects were significantly lower in cells pretreated with ethanol or acetate.
In cells pretreated with acetate or ethanol , the oxidative stress induced by arachidonic acid was also significantly lower.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2013  |  View Paper
Treatment with 2.0% (v/v) ethanol , an inhibitor of phospholipase D, decreased sulfur mustard-induced arachidonic acid release 40+/-7%.
Biochemical and biophysical research communications  •  2002  |  View Paper
This observation is consistent with the view that alcohol reduces platelet sensitivity to thrombotic stimuli by inhibition of arachidonic acid release and, therefore, subsequent thromboxane synthesis.
Alcoholism, clinical and experimental research  •  2000  |  View Paper
Conversion of [1-14C] palmitic to oleic acid and eicosatrienoic to arachidonic acid were inhibited in 400 mM ethanol treated cells suggesting an inhibition of delta 9 and delta 5 desaturase activity.
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia  •  1996  |  View Paper
Show More