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Last Updated: 2 years ago

Possible Interaction: Ethanol and Arachidonate

supplement:

Ethanol

supplement:

Arachidonate

Research Papers that Mention the Interaction

Previous studies showed that ethanol does not affect platelet stimulation by arachidonate, leading to the suggestion that reduced mobilization of arachidonate , rather than inhibition of its conversion to thromboxane A2, is responsible for inhibition by ethanol of thromboxane A2 formation.
Thrombosis research  •  1999  |  View Paper
Thus, in addition to inhibiting the mobilization of arachidonate for thromboxane formation that occurs with most agonists, ethanol can also inhibit aggregation and secretion through other effects on platelet responses.
Thrombosis and haemostasis  •  1988  |  View Paper
Previous research has demonstrated that prolonged exposure to ethanol results in alterations in the oxidative metabolism of arachidonic acid including lowered membrane levels of arachidonate , increased arachidonate peroxidation, and increased oxidation of arachidonate to prostaglandin E2.
Biochemical medicine  •  1979  |  View Paper
Addition of a second metabolic challenge, i.e., alcohol , led to loss of tissue polyunsaturates, particularly liver arachidonate.
Lipids  •  2007  |  View Paper
Treatment of PMN with ethanol (an inhibitor of PLD‐mediated phosphatidic acid formation), propranolol (a phosphatidic acid phosphatase inhibitor), or 4‐bromophenacylbromide (a PLA2 inhibitor), each suppressed fMLP‐stimulated arachidonate release.
FEBS letters  •  1996  |  View Paper
This study investigated the mechanism by which chronic ethanol feeding reduces arachidonate and other highly unsaturated fatty acids in pig liver phospholipids.
The Journal of clinical investigation  •  1994  |  View Paper
Second, ethanol appreciably inhibited the uptake and esterification of [3H]arachidonate into phospholipids of unlabeled cells.
The results reported herein suggest that ethanol stimulated [3H]arachidonate liberation from prelabeled macrophages by inhibiting AA reesterification into phospholipids rather than by enhancing phospholipase A2 activity.
Biochimica et biophysica acta  •  1993  |  View Paper
Chronic ethanol administration significantly decreased the percentage of arachidonate and significantly increased the linoleate: arachidonate ratio in the cortical synaptosomal phosphatidylinositol (PI) of rats.
Alcohol and alcoholism  •  1992  |  View Paper
In short term incubation (8 hr), ethanol (128-255 mM) enhanced the incorporation of labeled arachidonate into most phospholipids.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement  •  1987  |  View Paper
In animals matched for nutritional intake, ETOH caused a dose dependent lowering of the microsomal arachidonate content of heart, brain, and liver.
Prostaglandins, leukotrienes, and medicine  •  1982  |  View Paper
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