supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Apremilast
Research Papers that Mention the Interaction
“We investigated mechanisms by which the PDE4 inhibitor, apremilast , regulates acute effects of ethanol and GABAergic drugs in male and female mice.”
Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling“Chronic administration of apremilast (20 mg/kg) produced a stable reduction in EtOH consumption in both drinking tests with no effect on total fluid intake.”
“ Apremilast also reduces some aspects of general reward and increases EtOH 's aversive properties, which might also contribute to its ability to reduce EtOH drinking.”
“ Apremilast increased the acquisition of CPA to EtOH , reduced locomotor responses to a novel situation, and prolonged the duration of LORR and the recovery from acute motor incoordination induced by EtOH.”
“BACKGROUND In our companion paper, we reported that the phosphodiesterase type 4 inhibitor apremilast reduced ethanol ( EtOH ) intake and preference in different drinking models in male and female C57BL/6J mice.”
“CONCLUSIONS Our results suggest that ap emilast in creases the duration of EtO H in toxication by reducing AFT.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback