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Last Updated: 2 years ago

Possible Interaction: Ethanol and Apremilast

supplement:

Ethanol

Research Papers that Mention the Interaction

We investigated mechanisms by which the PDE4 inhibitor, apremilast , regulates acute effects of ethanol and GABAergic drugs in male and female mice.
Neuropharmacology  •  2020  |  View Paper
Chronic administration of apremilast (20 mg/kg) produced a stable reduction in EtOH consumption in both drinking tests with no effect on total fluid intake.
Alcoholism, clinical and experimental research  •  2018  |  View Paper
Apremilast also reduces some aspects of general reward and increases EtOH 's aversive properties, which might also contribute to its ability to reduce EtOH drinking.
Apremilast increased the acquisition of CPA to EtOH , reduced locomotor responses to a novel situation, and prolonged the duration of LORR and the recovery from acute motor incoordination induced by EtOH.
BACKGROUND In our companion paper, we reported that the phosphodiesterase type 4 inhibitor apremilast reduced ethanol ( EtOH ) intake and preference in different drinking models in male and female C57BL/6J mice.
CONCLUSIONS Our results suggest that ap emilast in creases the duration of EtO H in toxication by reducing AFT.
Alcoholism, clinical and experimental research  •  2018  |  View Paper