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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Ethanol
drug:
Apomorphine
Research Papers that Mention the Interaction
“ Ethanol also attenuated the inhibitory effect of apomorphine on turnover of striatal dopamine.”
“Unilateral injection of ethanol into the neostriatum of rats followed by intraperitoneal injection of either apomorphine or amphetamine elicited marked ipsilateral head-to-tail body turning.”
Effects of ethanol on turnover and function of striatal dopamine“The ethanol stimulus effect may be increased (i.e., stronger recognition) by N-cholinergic drugs (nicotine), dopaminergic drugs ( apomorphine ), and 5-HT3 receptor agonists (m-chlorophenylbiguanide).”
“A higher apomorphine dose (8 microM/kg) antagonized the locomotor depressant effects of 2.0 and 2.5 g/kg of ethanol in LS mice but did not alter the shape of the SS ethanol dose response curve for locomotor activity.”
“Upon withdrawal of ethanol, apomorphine decreased the time of transmission to water consumption in the rats of both sexes and prevented a decline in the endogenous ethanol levels, the latter effect being especially pronounced in the female rats.”
“Mice treated with ethanol for 7 days and then withdrawn for 24 hours showed a decreased hypothermic response to apomorphine.”
“Animals withdrawn from ethanol for 24 hr showed a decreased hypothermic response to apomorphine suggesting that changes in dopaminergic systems had occurred.”
“Collier, Hammond & Schneider (1976) reported that apomorphine , given orally, decreased the incidence of head twitches induced by ethanol withdrawal.”
“After administration of apomorphine , performance improved in alcohol dependent patients and deteriorated in healthy controls.”
“Improvement of cognitive performance in alcohol dependent patients after administration of apomorphine and deterioration in healthy controls provides evidence for an inverted U-shape relation between dopaminergic functioning and cognitive performance.”
“Among this set, apomorphine and topiramate blocked both nicotine and ethanol responses.”
Larval Zebrafish Model for FDA-Approved Drug Repositioning for Tobacco Dependence Treatment“CNS depressant effects of ethanol were not altered on repeated administration but CNS stimulatory effects of apomorphine increased.”
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