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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Antipyrine
Research Papers that Mention the Interaction
“ Ethanol treatment also enhanced the elimination of antipyrine in saliva.”
Ethanol induced modification of m-xylene toxicokinetics in humans.“Nevertheless, a tendency to increase the metabolic rate of antipyrine in xylene-exposed group (T1/2 approximately 6.8 h; ClAP approximately 1.40 cm3/s) and counteraction of ethanol (T1/2 approximately 15 h; ClAP approximately 0.63 cm3/s) should be noted.”
“Considerable individual variation occurred in the degree to which ethanol shortened plasma antipyrine half‐lifes; reduction ranged from 4 to 37 per cent of the initial antipyrine half‐life.”
“Rates of antipyrine elimination from plasma were accelerated by ethanol administration in each of the 6 volunteers.”
“The addition of antipyrine or aminopyrine to isolated hepatocytes derived from normal rats and incubated with ethanol caused a significant decrease in the oxidation of ethanol to acetate.”
Antipyrine and aminopyrine induce acetaldehyde accumulation from ethanol in isolated hepatocytes.“There was significant inhibition of antipyrine metabolism in primary suspensions by phenylbutazone (1.6 X 10(-3)M), dexamethasone (2 X 10(-4)M) and ethanol (1.3 X 10(-2)M, 0.75%).”
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