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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Anticonvulsants
Research Papers that Mention the Interaction
“Abstract The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment.”
Zonisamide, Topiramate, and Levetiracetam“It is now well demonstrated that several anticonvulsants have a role in the treatment of neuropathic pain and also in withdrawal from benzodiazepines, sedatives, and perhaps alcohol.”
“… anticonvulsants act synergistically' and similarities between the fetal anticonvulsant and alcohol syndromes have been … wonder whether palatal function may be particularly susceptible to the teratogenic effects of alcohol or anticonvulsants, or both, and suggest that if such an effect … this would be a useful diagnostic pointer in these disorders.”
“… anticonvulsants act synergistically' and similarities between the fetal anticonvulsant and alcohol syndromes have been … wonder whether palatal function may be particularly susceptible to the teratogenic effects of alcohol or anticonvulsants, or both, and suggest that if such an effect … this would be a useful diagnostic pointer in these disorders.”
“In epileptic patients, the use of ethanol can modify seizure initiation and subsequent seizure activity with reports of ethanol being both pro‐ and anticonvulsant.”
Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus“Peripherally produced NAS modulate some effects of ethanol intoxication (e.g., anxiolytic, antidepressant, and anticonvulsant effects ) in rodents.”
“Overall, the increase in acute EtOH withdrawal severity in female WSP and WSR mice after adrenalectomy and gonadectomy corroborate our recent evidence that withdrawal from a high dose of EtOH can be modulated by anticonvulsant steroids produced in the periphery.”
“Earlier work indicates that sensitivity to the anticonvulsant effect of ALLO was enhanced during ethanol (EtOH) withdrawal in rats and in C57BL/6 mice, an inbred strain with mild EtOH withdrawal.”
“Furthermore, in the hippocampal afterdischarge model in rats, ethanol dose-dependently raised the focal stimulation threshold and significantly increased the anticonvulsant efficacy of co-administered carbamazepine after acute application.”
“The most dramatic differences were observed with anticonvulsant treatment during ethanol withdrawal, when seizure susceptibility is significantly increased.”
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