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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
Research Papers that Mention the Interaction
“The clinical risk for bleeding in patients taking aspirin or NSAIDs is enhanced by the concomitant use of ethanol.”
Fatty acid ethyl ester, a non‐oxidative ethanol metabolite, reverses the inhibitory effect of ibuprofen on platelet aggregation“However, anti-inflammatory drugs and disinfection with alcohol or alcoholic substances should be avoided.”
“BACKGROUND Previous work from our laboratory revealed that administration of selected nonsteroidal anti-inflammatory drugs (NSAIDs)-aspirin, naproxen, nimesulide, and piroxicam-prevented some signs of oxidative stress produced in rat livers acutely intoxicated with ethanol.”
“In in vivo experiments on rats, oral preadministration of a low dose of ethanol protected the gastric mucosa from gastric lesions induced by subsequent oral administration of NSAIDs.”
“One possible explanation for this in vivo phenomenon is that the adaptive cytoprotection induced by ethanol protects the gastric mucosa from the direct cytotoxic effect of NSAIDs.”
“Pretreatment of cells with low (nontoxic) concentrations of ethanol protected cells from cell death induced by subsequent exposure to NSAIDs.”
“Presumably, the persistent use of NSAIDs and alcohol for analgesic purposes resulted in the development of the perforated gastric ulcer.”
“For example, a 73-year-old man with blood pressure 170/100 mm Hg who …%) (i.e., poor INR control, a powerful predictor of bleeding events) and excessively uses nonsteroidal antiinflammatory drugs (… alcohol might be assigned an ORBIT score of 0 (… a HAS-BLED score of 5 (high risk).”
“The main risk factors … gastrointestinal adverse effects during NSAID therapy are: a high dose regimen; age over 65 years; a … gastric or duodenal ulcer or gastrointestinal bleeding; heavy use of both alcohol and tobacco; and concomitant treatment with a corticosteroid, antiplatelet …, anticoagulant, or selective serotonin reuptake inhibitor (SSRI) antidepressant.”
“Associations of alcohol to risk for rectal cancer may be related to cellular hyperproliferation and may be modified by NSAID use.”
“Factors that increase the risk of bleeding with aspirin and other NSAIDs include coexisting coagulation abnormalities and the simultaneous use of alcohol or anticoagulants.”
“This observation underlines the danger in associating nonsteroidal anti-inflammatory drugs and ethanol.”
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