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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Anti-Anxiety Agents
Research Papers that Mention the Interaction
“Both anxiolytics showed only slight additive interactions with the present dose of alcohol.”
Effects of buspirone and diazepam, alone and in combination with alcohol, on skilled performance and evoked potentials.“Many of these medications had the potential for adverse interactions with alcohol , including opioids, anxiolytics , antidepressants, hypnotics, antipsychotics, and mood regulators.”
“A combination of anxiolytics with alcohol increased the risk of dementia and did not reverse the cognitive pathology.”
“Subjects are especially vulnerable when (a) antianxiety drugs are first introduced; (b) the dose is increased; and (c) these agents are taken in combination with alcohol and other drugs.”
“At the pharmacodynamic level, ethanol can enhance the deleterious effects of sedatives, certain anxiolytics , sedative antidepressants and antipsychotics, and anticholinergic agents, on performance.”
“Mechanisms of lethal interactions between moderate overdoses of ethanol and anxiolytics / opiates / sedatives are poorly understood.”
“Chronic exposure to ethanol (EtOH) alters receptor-mediated responses and the numbers of these channels and specific subunits; as well as induces anxiolytic , sedative, and anesthetic activity in the human brain.”
“… anxiolytics … alcohol at least twice a week (odds ratio=2.42; 95% confidence interval=1.30-4.51), to be binge drinkers (odds ratio=1.86; ….43) and to be heavy alcohol consumers (odds ratio=2.22; 95% confidence interval= 1.13-4.39) than men not using psychotropics.”
“ Central ethanol exposure appears to exert antianxiety effects that attenuate apneic disruptions but under the state of withdrawal, the cues associated with such effects elicit an opposite reaction.”
Learning Experiences Comprising Central Ethanol Exposure in Rat Neonates: Impact Upon Respiratory Plasticity and the Activity of Brain Catalase.“High ethanol intake is well known to induce both anxiolytic and anxiogenic effects, in correlation with chromatin remodeling in the amygdaloid brain region and deficits in cell proliferation and survival in the hippocampus of rodents.”
“Peripherally produced NAS modulate some effects of ethanol intoxication (e.g., anxiolytic , antidepressant, and anticonvulsant effects) in rodents.”
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