Possible Interaction: Ethanol and Androstenedione

“ Androstenedione levels were significantly lowered and the testosterone:androstenedione ratio significantly elevated by alcohol among both OC- and OC+ subjects.”

“ Ethanol lowered the mean testicular concentrations of testosterone (by 63–74%), androstenedione (49–81%), 17‐hydroxyprogesterone (60–76%), progesterone (29–67%) and pregnenolone (12–25%).”

“The ratios between the 3-sulphates of 5α-androstane-3α , 17β-diol and androsterone and between the monosulphates of 5α-androstane-3β,17β-diol and 3β-hydroxy-5α-androstan-17-one also increased during ethanol metabolism.”

“Results revealed that administration of AN to pregnant dams at a dose that does not influence fetal growth by itself can retard fetal growth in the presence of alcohol , PF, COC or RS.”

“In Krebs-Ringer bicarbonate buffer, EtOH inhibited both the conversion of pregnenolone to progesterone and androstenedione to testosterone.”

“… ethanol reduced the concentration of testosterone (16%, P less than 0.… the concentrations of pregnenolone (60%, P less than 0.001), androstenedione (86%, P less than 0.001) and dehydroepiandrosterone (81%, P less than 0.001); … not change concentrations of progesterone and 17 alpha-hydroxyprogesterone in the incubation medium.”

“Under in vitro conditions, we observed that ethanol selectively inhibited the conversion of androstenedione to testosterone, but that it had a much more general effect under in vivo conditions.”