supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ethanol
drug:
Amprenavir
Research Papers that Mention the Interaction
“However, ethanol significantly decreased the IC(50) of type II PIs, indinavir and ritonavir, and markedly increased the IC(50) of amprenavir and darunavir.”
Differential effects of ethanol on spectral binding and inhibition of cytochrome P450 3A4 with eight protease inhibitors antiretroviral drugs.“A low concentration of the NMDA antagonist APV (5 μm) mimicked the inhibition of ethanol of persistent activity with no change in activity after washout.”
Ethanol Inhibits Persistent Activity in Prefrontal Cortical Neurons“Preincubation of the slices with 25 microM APV reduced the relative degree of inhibition caused by EtOH suggesting that N-methyl-D-aspartate (NMDA)-receptor-mediated events can be affected by EtOH.”
“On the other hand, the nicotine + ethanol combination increased APV and caused attenuation of the excitatory effects of nicotine in dogs.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback