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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Amphotericin B
Research Papers that Mention the Interaction
“The combination of the ethanol extract and hexane fraction with amphotericin B and essential oil enhanced their antifungal activity, reducing the concentration of each substance needed to kill 100% of the inoculum.”
Anti-cryptococcal activity of ethanol crude extract and hexane fraction from Ocimum basilicum var. Maria bonita: mechanisms of action and synergism with amphotericin B and Ocimum basilicum essential oil“However, Amphocil and ABPLC, but not Fungizone, when dispersed in an aqueous solution containing 5 to 25% ethanol , induced a statistically significant improvement in lesion size from week 2 or 3 onward (a total of 15 mg of AmB per kg of body weight was applied over 3 weeks).”
“Synergy also appeared to be present for the combinations of amphotericin B and dimethyl formamide or ethanol.”
“With exponential phase cells, in the presence of AmB , the consumption of glucose and the production of ethanol , trehalose, and glycerol continuously decreased with time, and after 25 min, the metabolism was blocked.”
Effects of amphotericin B on glucose metabolism in Candida albicans blastospores evidenced by 13C NMR.“In general the presence of 10(-6) M AMB reduces the glucose consumption and the ethanol production while favouring the glycerol and trehalose formation.”
“ Amphotericin B has been found to exert a marked influence on the glucose consumption and the production of all metabolites; for example, at 1 microM, the glucose consumption and the production of ethanol decrease while the production of glycerol and trehalose increases.”
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