Possible Interaction: Ethanol and Amphetamine

“Conversely, amphetamine reduced the test-retest reliability of the Wonderlic Personnel Test, but alcohol appeared to counteract this effect of amphetamine.”

“No differences were shown between the effects of ethanol-amphetamine and ethanol-lactose on the performance …, Minnesota manipulation, Purdue peg board, Maudsley Personality Inventory, pursuit rotor or digit span tests; but ethanol … amphetamine produced less impairment of performance of coding, mental … making tests than did ethanol plus a placebo.”

“These experiments indicate that, when ethanol and amphetamine are used together, each drug modifies some of the effects produced by the other in a manner that cannot be predicted on the assumption that a depressant versus stimulant competition is operative.”

“It is known that alcohol plays a major role in the causation of unnatural deaths and that stimulants like cocaine and amphetamine are often implicated in aggressive acts or violence.”

“Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine ) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction.”

“Unilateral injection of ethanol into the neostriatum of rats followed by intraperitoneal injection of either apomorphine or amphetamine elicited marked ipsilateral head-to-tail body turning.”

“The reduction in the abusive consumption of alcohol and in the illicit use of substances like amphetamines by professional drivers depends not only on policies addressing prevention and treatment for drug abuse, but also on integrated policies ensuring better working and health conditions to the truck drivers.”

“Similarly, small doses of amphetamines can cause a positive stimulating effect, improving certain cognitive functions, such as vigilance, but it decreases when they are overused and combined with alcohol.”

“Chi‐squared tests revealed that when alcohol was used in combination with any of cannabis, psilocybin, MDMA, cocaine, amphetamine , methylphenidate (ps < 0.01) or LSD (p < 0.05) its initial use preceded the administration of the other substance.”

“Although alcohol is the primary source of problems for the workplace, other drugs such as amphetamines , cocaine, marijuana, and tobacco are also troublesome.”

“ Alcohol exacerbates and amphetamine ameliorates the slowing of reaction time (RT) produced by inert gas narcosis.”

“In methamphetamine (MAP) addicts, long-term ethanol ingestion 3-4 times per week induced an increased rate of p-hydroxylation of MAP and amphetamine (AMP).”