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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Amantadine
Research Papers that Mention the Interaction
“In contrast to reports indicating that amantadine antagonized ethanol depression in rodents, amantadine did not significantly alter the degree of ethanol intoxication in humans.”
Interaction of apomorphine and amantadine with ethanol in men.“In contrast, amantadine reduced both alcohol SIP (40 mg/kg) and water SIP (40 and 60 mg/kg).”
Behavioral effects of aminoadamantane class NMDA receptor antagonists on schedule-induced alcohol and self-administration of water in mice“Administration of ATD , 0.5 mM/kg IP, prior to a narcotic dose of ETOH significantly decreased the central depressant action of ETOH, as measured by the duration of ETOH-produced narcosis in mice.”
“This effect of ethanol could be partially antagonized by amantadine , a non‐selective NMDA receptor antagonist and dopamine releaser, at a dose of 200 mg/kg i.p.”
Involvement of the corticostriatal glutamatergic pathway in ethanol‐induced ascorbic acid release in rat striatum
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