Possible Interaction: Ethanol and Alprostadil

“ Prostaglandin E1 (PGE1) and prostanoid precursor fatty acids enhance the acute sedative effects of ethanol in mice, and reduce the intensity of withdrawal after chronic exposure to ethanol.”

“ Ethanol also potentiated platelet synthesis of PGE1 from dihomo-gamma-linolenic acid.”

“The derivative possibility that “down regulation” of PGE1 systems is involved in the development of ethanol dependence is supported by data showing that PGE1 administered to mice following chronic exposure to ethanol reduced withdrawal syndrome intensity.”

“These interactions may derive from the fluidizing effects of ethanol on lipid-containing cell membranes, and suggest a possible role for PGE1 as a mediator of certain acute effects of ethanol.”

“cAMP accumulation generated by the other adenylyl cyclases was, however, increased by incubation of cells with ethanol in the presence of stimulatory agonists (e.g., prostaglandin E1).”

“ Ethanol can inhibit delta-6-desaturase (d-6-d) activity which is necessary for the conversion of LA to GLA9 and chronic ethanol consumption induces decreased production of PGE1. "'”

“Withdrawal from alcohol will lead to a precipitous fall in PGE1.”

“Alcoholics will tend to have raised PGE1 concentrations while drinking, but, because precursor supplies are limited, when alcohol concentrations fall PGE1 concentrations may fall sharply leading to depression.”

“ Ethyl alcohol stimulates PGE1 production whereas lithium inhibits it.”

“ Alcohol , vitamin C and chloroquine selectively enhance DGLA conversion to PGE1 : opiates may either enhance of inhibit PGE1 formation selectively depending on receptor type.”

“Using selective agonists, we found that butaprost, an EP2R agonist, and PGE1 alcohol , an EP2R and EP2R/EP4R agonist, inhibited major histocompatibility complex class II expression and enhanced interleukin‐10 production from DC.”

“Acute exposure to ethanol increased the PGE1-stimulated levels of cAMP and IR-beta-EP, whereas chronic exposure to ethanol resulted in diminished cAMP responses to PGE1.”

“ PGE1 decreased cytochrome P‐450 content, normalized NADPH oxidation, NADPH‐induced chemoluminiscence and SOD activity in the liver of alcohol‐treated rats.”