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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Alprazolam
Research Papers that Mention the Interaction
“Low dose alprazolam, diazepam, and ethanol produced significantly fewer side effects than 2 mg alprazolam , but significantly more than placebo.”
Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers“The combination of alprazolam and alcohol increased behavioral aggression more than would have been predicted from the sum of the single effects, confirming clinical reports of behavioral dyscontrol.”
“ABSTRACT Background: Alprazolam is a commonly used benzodiazepine in clinical practice, and when coingested with ethanol, alprazolam can increase behavioral irritability and aggression.”
“Conclusions: Ethanol might increase the toxicity of alprazolam by inhibiting the activity of CYP3A4, although other pharmacokinetic processes may be affected.”
“ Ethanol could change the conformation of CYP3A4 and affect alprazolam binding.”
“In silico molecular docking was applied to analyze the change in the CYP3A4–alprazolam-binding conformation when ethanol was coadministered with alprazolam.”
“Results: Compared with alprazolam administered alone (2 mg/kg), the Cmax of alprazolam increased when ethanol was simultaneously administered at 3 g/kg.”
“The concentrations of alprazolam significantly increased by 39%, 17%, 105%, and 642% at 5, 10, 30, and 120 min intervals in the brain when coadministered with ethanol , respectively.”
“Driving behaviour influenced by alcohol and alprazolam was characterised by different feature importance, indicating that the two interventions influenced driving behaviour in a different way.”
“Results: Alprazolam and alcohol significantly affected the main parameters of driving in the simulator and affected scores of safe driving and alprazolam increased the odds ratio of a virtual crash.”
“The production of 4-OH alprazolam , one main metabolite of alprazolam, was weakly inhibited by higher dose of ethanol , but not alpha-OH alprazolam.”
“These results using a human liver microsomal preparation show that the production of 4-OH alprazolam is weakly inhibited by ethanol but not alpha-OH alprazolam.”
“Administration of lorazepam or alprazolam produced a dose-dependent decrease in the binding of [3H]Ro 15-1788 to brain tissue after administration of either saline or 30% volume/kg ethanol.”
Effects of acute administration of alcohol on in vivo binding of [3H]Ro 15-1788 to mouse brain.
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