Possible Interaction: Ethanol and Alpha-lipoic acid

“ Thioctic acid or glutamine decreases ethanol intake.”

“The ALH + ALA produced stronger effects on the bone volume ratio (BV/TV), trabecular thickness (Tb.”

“These results seem to indicate that ALA intervention prevents bone loss in senile female rats with ALH consumption.”

“It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication.”

“Pretreatment with DP or LA only prevented GPx activity changes induced by ethanol.”

“ Lipoic acid (10 or 30 mg/kg) or Alda-1 (a positive control, 10 mg/kg) was given 45 min before the ethanol treatment.”

“RESULTS The results indicate that AL do se-dependently reduced the maintenance, the break point of EtO H se lf-administration under a PR and the reinstatement of EtOH seeking behavior without suppressing saccharin self-administration.”

“This laboratory showed that ethanol augments apoptosis in fetal rhombencephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxidants prevents ethanol-associated apoptosis.”

“On the other hand, lipoic acid treatment reversed all these biochemical indices as well as the histopathological changes induced by ethanol.”

“Conclusions: The results demonstrate that direct exposure to ethanol significantly enhanced contractile dysfunctions mediated by In vitro ischemia followed by re-oxygenation and that the presence of LA significantly inhibits this effect of ethanol. (”

“Secondly, we determined if α-lipoic acid LA ) could alter the response to ethanol + In vitro ischemia.”

“d) LA completely reversed the effects of ethanol on contractile responses following In vitro ischemia except for carbachol.”

“Addition of 25 µM ALA to 1% ethanol during oocyte maturation decreased ROS level and elevated Thiolcontent.”

“Conclusion The current findings demonstrate that ALA can diminish the effect of ethanol , possibly by decreasing the ROS level and increasing Thiolcontent during oocyte maturation.”

“Furthermore, supplementation of maturation medium with ALA attenuated the effect of 1% ethanol and significantly increased the blastocyst formation and hatching rate as compared to control and ethanol groups.”