Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Ethanol and Alpha-lipoic acid



Research Papers that Mention the Interaction

Thioctic acid or glutamine decreases ethanol intake.
International review of neurobiology  •  1960  |  View Paper
The ALH + ALA produced stronger effects on the bone volume ratio (BV/TV), trabecular thickness (Tb.
These results seem to indicate that ALA intervention prevents bone loss in senile female rats with ALH consumption.
Zeitschrift für Gerontologie und Geriatrie  •  2019  |  View Paper
It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication.
Oxidative medicine and cellular longevity  •  2019  |  View Paper
Pretreatment with DP or LA only prevented GPx activity changes induced by ethanol.
Alcoholism, clinical and experimental research  •  2019  |  View Paper
Lipoic acid (10 or 30 mg/kg) or Alda-1 (a positive control, 10 mg/kg) was given 45 min before the ethanol treatment.
Alcohol  •  2016  |  View Paper
RESULTS The results indicate that AL do se-dependently reduced the maintenance, the break point of EtO H se lf-administration under a PR and the reinstatement of EtOH seeking behavior without suppressing saccharin self-administration.
Alcoholism, clinical and experimental research  •  2013  |  View Paper
This laboratory showed that ethanol augments apoptosis in fetal rhombencephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxidants prevents ethanol-associated apoptosis.
Brain Research  •  2011  |  View Paper
On the other hand, lipoic acid treatment reversed all these biochemical indices as well as the histopathological changes induced by ethanol.
Pharmacology  •  2007  |  View Paper
Conclusions: The results demonstrate that direct exposure to ethanol significantly enhanced contractile dysfunctions mediated by In vitro ischemia followed by re-oxygenation and that the presence of LA significantly inhibits this effect of ethanol. (
Secondly, we determined if α-lipoic acid LA ) could alter the response to ethanol + In vitro ischemia.
d) LA completely reversed the effects of ethanol on contractile responses following In vitro ischemia except for carbachol.
Molecular and Cellular Biochemistry  •  2005  |  View Paper
Addition of 25 µM ALA to 1% ethanol during oocyte maturation decreased ROS level and elevated Thiolcontent.
Conclusion The current findings demonstrate that ALA can diminish the effect of ethanol , possibly by decreasing the ROS level and increasing Thiolcontent during oocyte maturation.
Furthermore, supplementation of maturation medium with ALA attenuated the effect of 1% ethanol and significantly increased the blastocyst formation and hatching rate as compared to control and ethanol groups.
Cell journal  •  2021  |  View Paper