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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“Supplementation of AKG along with ethanol significantly improved liver function (HEF: 76.42 ± 5.3; Tpeak: 155 ± 34 sec; T1/2peak: 455 ± 22 sec).”
Alpha-ketoglutarate mediated hepatoprotection against alcohol induced toxicity: in vivo functional observation studies in Sprague Dawley rats using gamma scintigraphy“Food supplementation with 10-mM AKG alleviated toxic effects of 8% ethanol added to food, and improved fly development.”
“It can be concluded that both a stimulation of some components of antioxidant defense and the increase in ADH activity may be responsible for the protective effects of AKG diet supplementation in combination with ethanol.”
“spectroscopic analysis showed that ethanol feeding reduced the urinary excretion of citrate and 2-oxoglutarate (by approximately 50%), suggesting decreased citric acid cycle activity.”
“GABA-AT requires a-oxoglutarate as the acceptor of the amino group, and during ethanol intoxication the concentration of a-oxoglutarate is diminished in brain while the concentration of glutamate, the substrate of GAD, is increased (HAKKINEN & KULONEN, 1961).”
“ Ethanol halved the content of 2-oxoglutarate in the cytosol and more than trebled that of glutamate in the mitochondria.”
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