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Last Updated: 3 years ago

Possible Interaction: Ethanol and Alpha-Ketoglutarate



Research Papers that Mention the Interaction

Supplementation of AKG along with ethanol significantly improved liver function (HEF: 76.42 ± 5.3; Tpeak: 155 ± 34 sec; T1/2peak: 455 ± 22 sec).
Drug and chemical toxicology  •  2019  |  View Paper
Food supplementation with 10-mM AKG alleviated toxic effects of 8% ethanol added to food, and improved fly development.
It can be concluded that both a stimulation of some components of antioxidant defense and the increase in ADH activity may be responsible for the protective effects of AKG diet supplementation in combination with ethanol.
Alcohol  •  2016  |  View Paper
spectroscopic analysis showed that ethanol feeding reduced the urinary excretion of citrate and 2-oxoglutarate (by approximately 50%), suggesting decreased citric acid cycle activity.
Clinical science  •  1991  |  View Paper
GABA-AT requires a-oxoglutarate as the acceptor of the amino group, and during ethanol intoxication the concentration of a-oxoglutarate is diminished in brain while the concentration of glutamate, the substrate of GAD, is increased (HAKKINEN & KULONEN, 1961).
Journal of neurochemistry  •  1979  |  View Paper
Ethanol halved the content of 2-oxoglutarate in the cytosol and more than trebled that of glutamate in the mitochondria.
The Biochemical journal  •  1975  |  View Paper