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Possible Interaction: Ethanol and Allopurinol

supplement:

Ethanol

Research Papers that Mention the Interaction

Ethanol infusion modestly reduced ALLO levels in all subjects, independent of genotype or naltrexone exposure.
Alcoholism, clinical and experimental research  •  2010  |  View Paper
RationaleAllopregnanolone ALLO ) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR).
Psychopharmacology  •  2014  |  View Paper
ALLO selectively modulated ethanol intake patterns associated with the onset and maintenance of self-administration, while leaving appetitive (i.e., ethanol seeking) measures unaltered.
Behavioural Brain Research  •  2007  |  View Paper
Pretreatment by ALO before E and L-DOPA before IND resulted in the increase of TG in comparison with drugs alone.
We found: 1) significant (p < 0.01) inhibition of GL activity after administration of E and IND and also ALO , as well as after pretreatment with ALO before E and PX before IND.
Physiological research  •  2001  |  View Paper
All these … inhibited by allopurinol and were sensitive to heating for 5 … 100 degrees C. The biotransformation of ethanol to acetaldehyde in the presence of purines as cosubstrates was accompanied by the formation of … and 1HEt radicals as detected by GC-MS, and the process was inhibited by allopurinol.
Teratogenesis, carcinogenesis, and mutagenesis  •  2001  |  View Paper
Similarly, sucralfate (0.031-0.250 g/kg) orally and allopurinol (0.025-0.050 g/kg) intravenously inhibited vascular permeability caused by ethanol and treatment with N-ethylmaleimide before sucralfate or allopurinol reduced their inhibitory effects.
Journal of ethnopharmacology  •  1997  |  View Paper
These ethanol effects decreased when the animals were given superoxide dismutase plus catalase (scavenger of O2− and H2O2, respectively), allopurinol , or oxypurinol (xanthine oxidase inhibitors).
Digestive Diseases and Sciences  •  1996  |  View Paper
The administration of allopurinol prior to the ethanol load prevented the changes in liver and cerebellar non-heme iron content.
Biochemical pharmacology  •  1994  |  View Paper
The administration of allopurinol prior to the ethanol load prevents the changes in non-heme iron and trace elements.
Free radical research communications  •  1991  |  View Paper
Desferrioxamine, an iron chelator, increased survival in cells treated with doxorubicin plus ethanol by up to 60% (half-maximal …, abolished the decrease in cell number due to doxorubicin plus ethanol at concentrations greater than 0.1 mM. Allopurinol , an inhibitor of xanthine … of doxorubicin plus ethanol on cell ….05).
Cancer research  •  1991  |  View Paper
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