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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Allopurinol
Research Papers that Mention the Interaction
“Although allopurinal was partially protective against ethanol damage when administered chronically, observations in other models of injury suggest that this action is independent of its inhibitory effect on xanthine oxidase.”
Gastric injury induced by ethanol and ischemia-reperfusion in the rat“These ethanol effects decreased when the animals were given superoxide dismutase plus catalase (scavenger of O2− and H2O2, respectively), allopurinol , or oxypurinol (xanthine oxidase inhibitors).”
“All these … inhibited by allopurinol and were sensitive to heating for 5 … 100 degrees C. The biotransformation of ethanol to acetaldehyde in the presence of purines as cosubstrates was accompanied by the formation of … and 1HEt radicals as detected by GC-MS, and the process was inhibited by allopurinol.”
“Furthermore, enteral ethanol caused free radical adduct formation, values that were reduced by approximately 40% by allopurinol.”
“Similarly, sucralfate (0.031-0.250 g/kg) orally and allopurinol (0.025-0.050 g/kg) intravenously inhibited vascular permeability caused by ethanol and treatment with N-ethylmaleimide before sucralfate or allopurinol reduced their inhibitory effects.”
“The administration of allopurinol prior to the ethanol load prevented the changes in liver and cerebellar non-heme iron content.”
“The administration of allopurinol prior to the ethanol load prevents the changes in non-heme iron and trace elements.”
“Desferrioxamine, an iron chelator, increased survival in cells treated with doxorubicin plus ethanol by up to 60% (half-maximal …, abolished the decrease in cell number due to doxorubicin plus ethanol at concentrations greater than 0.1 mM. Allopurinol , an inhibitor of xanthine … of doxorubicin plus ethanol on cell ….05).”
“…%allopurinol or DMSO significantly (… extent of the ethanol injury (11.1 +/- 0.8 and 11.9 +/- 0.9 mm2, respectively, vs. 19.2 +/- 1.1 mm2, n = 10) and …% solutions (10.4 +/- 0.9 and 10.2 +/- 0.8 mm2, respectively, vs. 19.2 +/- 1.1 mm2, n = 10).”
“ Allopurinol (100 mg/l) inhibited the toxic effects seen with ethanol + hypoxia.”
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