Possible Interaction: Ethanol and Alkaline Phosphatase

“Results: Ethanol significantly suppressed ALP activity, decreased gene expression of OCN and BMP2, lowered levels of RUNX2 protein, and reduced immunofluorescence staining of OCN and COL1 and calcium formation of hBMSCs.”

“ Ethanol feeding for 60 days resulted in significant increases in the activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase.”

“ Brush-border alkaline phosphatase … chronic ethanol ingestion as compared to ad libitum-fed control animals and administration of vitamin D to animals ingesting ethanol restored alkaline phosphatase activitymthe … pathway and that changes in alkaline phosphatase and calcium transport, although both affected by vitamin D, may represent independent metabolic consequences.”

“A synergistic effect was observed between alcohol and smoking ( AP 0.40, 95% CI 0.15 to 0.64), indicating that 40% of the cases among the double exposed are due to the interaction per se.”

“There was also a significant elevation in plasma cytokines in patents with alcohol associated AP within 72 h of symptom onset.”

“ Ethanol showed an enhancing effect on angiogenesis and activity of alkaline phosphatase.”

“Results from the multivariable analyses suggested a weak inverse association of alcohol with ALP [−1.5% (−1.7, −1.3)], which differed from the strong positive effect found in genetic-IV analyses [11.6% (6.8, 16.4)] (pdiff<0.0001).”

“The addition of ethanol in the culture medium resulted in a significant increment of sucrase and alpha 2,6-sialyltransferase activities in both cell lines, as well as the beta 1,4GalNAc-transferase activity in CaCo-2 cells and alkaline phosphatase activity in HT-29 cells.”

“ AP activity was significantly decreased by high doses of ethanol (2-5 g/l).”

“Human bone cell protein concentrations and alkaline phosphatase total activity were significantly reduced after exposure to 1% ethanol for 72 hours, but not with lower concentrations of ethanol.”