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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Aldesleukin
Research Papers that Mention the Interaction
“ Ethanol decreased TSF in a dose and route‐dependent manner.”
“We conclude that ethanol (and/or its metabolites) reduces TSF via humoral and neural mechanisms involving vagal pathways, muscarinic receptors and nitric oxide.”
Sphincter of Oddi function in the Australian brush‐tailed possum is inhibited by intragastric ethanol“Serum levels of IL-2 and TNF-alpha were markedly higher than those of ethanol group and saline groups (P<0.05).”
“ Interleukin 2 synthesis by murine splenocytes was inhibited by ETH in a concentration-related manner; the lowest concentrations of ETH caused an increase in interleukin 2 synthesis.”
“The present work examines the mechanisms underlying ethanol-induced dysfunction of CD4(+) T lymphocytes based on the hypothesis that ethanol downregulates lipid raft-mediated TCR signal transduction and resultant IL-2 production.”
“However, the capacity of exogenously supplied IL-2 to stimulate proliferation of T cells that had previously acquired IL-2 receptors was suppressed by ethanol in a dose-dependent manner, and this suppression was monophasic.”
“Using a combination of pharmacology, optogenetics, and phenotypic analyses we determine that ethanol activates a Gαs-cAMP-protein kinase A signaling pathway in IL2 neurons to stimulate nematode locomotion.”
Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans“It was … their ethanol intoxication (13 days; total dose, … of blood cytokines IFNgamma, IL-2 , IL-4, IL-10, increases the concentration of IL-6, suppresses the immune responses, and reduces the … to the control, which testifies to the greater damage of Th1 cells in comparison to Th2 lymphocytes.”
“ Ethanol consumption resulted in a reduction of the production of IL-2 , IL-4, and IL-6 as well as the basal and cytokine-activated NK cell cytolytic activity and IFN-gamma production in splenocytes.”
“The net result of changes in TLR‐mediated and co‐stimulatory signals may determine the altered immunological status induced by acute consumption of alcohol.”
“BACKGROUND Chronic administration of ethanol increases plasma prolactin levels and enhances estradiol's mitogenic action on the lactotropes of the pituitary gland.”
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