Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Ethanol and Acitretin

supplement:

Ethanol

Research Papers that Mention the Interaction

Possible esterification of acitretin to etretinate in the presence of ethanol has been reported.
The British journal of dermatology  •  2000  |  View Paper
100 days), since acitretin is potentially esterified in vivo by ethanol into etretinate [4, 5].
Dermatology  •  1999  |  View Paper
With monkey and dog cells, traces of etretinate were found without ethanol addition, but the esterification of acitretin was highly enhanced by ethanol.
With rat and human hepatocytes, etretinate was detectable only when ethanol was co-administered with acitretin.
Dermatology  •  1994  |  View Paper
Co-administration of acitretin and ethanol to rats resulted in a maximum plasma concentration of etretinate at approximately 1 h after dosing.
The results of our study in the rat could indicate that the presence of etretinate in plasma of some patients being treated with acitretin may result from the intake of alcohol.
Xenobiotica; the fate of foreign compounds in biological systems  •  1992  |  View Paper