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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ABSTRACT While in vitro results at clinically relevant concentrations do not predict abacavir (1592U89) interactions with drugs highly metabolized by cytochrome P450, the potential does exist for a pharmacokinetic interaction between abacavir and ethanol , as both are metabolized by alcohol dehydrogenase.”
“The geometric least squares mean area under … curve extrapolated to infinite time for abacavir increased 41% (from 11.07 to 15.62 μg · h/ml), and the … increased 26% (from 1.42 to 1.79 h) in the presence of ethanol (mean ethanol maximum concentration … of 498 μg/ml).”
“The percentages of abacavir dose recovered in urine as abacavir and its two major metabolites were each altered in the presence of ethanol , but there was no change in the total percentage (≈50%) of administered dose recovered in the 12-h collection interval.”
Pharmacokinetic Interaction of Abacavir (1592U89) and Ethanol in Human Immunodeficiency Virus-Infected Adults“Additionally, ethanol inhibits the metabolism of abacavir [16].”
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