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Last Updated: 5 months ago

Possible Interaction: Ethanol and 8-Chloro-Cyclic Adenosine Monophosphate

Research Papers that Mention the Interaction

To delineate these effects, we used PKA pathway inhibitors (adenylyl cyclase [AC], cAMP , and PKA) to modulate the effects of alcohol on dust-stimulated TNF-α release in the bronchial epithelial cell line, BEAS-2B.
Alcoholism, clinical and experimental research  •  2016  |  View Paper
Further analysis show that ethanol decreases steady-state intracellular cAMP levels, and thus depletes phosphorylation of cAMP-response element binding protein (p-CREB), the key transcription factor that regulates transcription of PGC-1α gene.
PloS one  •  2014  |  View Paper
Ethanol significantly reduced intracellular cAMP production upon adenosine stimulation.
PloS one  •  2012  |  View Paper
Pretreatment with alcohol was also associated with increased intracellular cAMP.
Virology  •  2003  |  View Paper
Ethanol added acutely prevents D2L receptor inhibition of cAMP production.
The Journal of pharmacology and experimental therapeutics  •  2001  |  View Paper
Moreover, basal (i.e. unstimulated) cAMP levels were increased at 2 hr of ethanol exposure.
Biochemical pharmacology  •  1998  |  View Paper
Activation of phospholipase D required extracellular Ca2+ … was regulated by protein kinase C. Ethanol treatment of cells also inhibited by 60-…-dependent release of arachidonic acid and cAMP but had no effect on increased cAMP synthesis after addition of … acid or on phospholipase A2 activity measured in cell extracts.
The Journal of cell biology  •  1995  |  View Paper
The noted stimulation of cAMP generation by ethanol was dose-dependent and required concurrent activation of adenylyl cyclase through the stimulatory G protein.
Alcoholism, clinical and experimental research  •  1995  |  View Paper
In cultured trophoblasts, EtOH treatment increased both epinephrine and 16,16'-dimethylprostaglandin E2 (dm-PGE2)-dependent cAMP production at varying ligand concentrations, suggesting an increased capacity to respond.
Biochemical pharmacology  •  1994  |  View Paper
EtOH also increased estradiol (E2) secretion by unstimulated JEG cells in a dose- and time-dependent manner and increased cAMP stimulated E2 secretion > 2-fold following 4 days of pretreatment with EtOH.
EtOH decreased in a dose-dependent manner the secretion of progesterone (P4) in response to cAMP when added with cAMP or when cells were pretreated with EtOH for 2 days.
Alcoholism, clinical and experimental research  •  1994  |  View Paper
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