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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
4-Hydroxybutyric Acid
Research Papers that Mention the Interaction
“Coingestion of ethanol did not significantly affect renal clearance of GHB, but urine GHB concentrations were lower in the first 3 h when ethanol and GHB were coingested (p = 0.039).”
GHB urine concentrations after single-dose administration in humans.“ GOBA 1.0 g + alcohol (0.36 +/- 0.027 mg/ml) impaired reactive skills more than GOBA 2.0 g did but no potentiation was seen.”
“This is a substantial downside of the GHB rapid screening, since the combination of GHB and ethanol is common.”
“The conversion of 1,4-BD to GHB was inhibited competitively by EtOH with an apparent Ki of 0.56 mM. Therefore, the coingestion of 1,4-BD and EtOH might increase the concentrations and the effects of 1,4-BD itself.”
“Clinical trials have demonstrated that 50–100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol.”
“Both gamma-hydroxybutyric acid GHB ) and flunitrazepam are often used illicitly in combination with ethanol.”
Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male rats.“TRH also failed to reverse the hypothermia induced by the combination of ethanol and baclophen or GHBA , and the characteristic neurological effects of TRH e.g. tremor, increased muscle tone, and increased respiratory rate were reduced.”
“Diazepam or γ-hydroxybutyrate , but not baclofen, prevented the changes in both GABAA receptor pharmacology and subunit mRNA levels induced by ethanol withdrawal.”
“Collectively, the results of the present study demonstrate that a non-sedative and anxiolytic dose of GHB effectively reduced voluntary ethanol intake in sP rats.”
“ GHB significantly reduced ethanol intake at doses of 300 and 400 mg/kg; statistical significance occurred only at the 15-min and 30-min observation times.”
“The rapid onset of the reducing effect of GHB on ethanol intake, as well as its anxiolytic effect, are discussed in terms of adding further support to the hypothesis that GHB may control alcohol craving and consumption in humans by substituting for ethanol's reinforcing effects.”
“The presence of cross-tolerance between GHBA and ethanol is discussed in terms of common pathways of neuroadaptation to chronic GHBA and ethanol.”
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