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Last Updated: 2 months ago

Possible Interaction: Ethacrynic Acid and Glutathione

Research Papers that Mention the Interaction

Ethacrynic acid inhibits the isoenzymes of GSH transferase with 50% inhibitory concentration values ranging from 0.3 to 6.0 microM and has been shown to restore sensitivity to alkylating agents in drug-resistant animal tumor models.
Cancer research  •  1991  |  View Paper
RESULTS The results revealed that EA (0.01-10 μM) significantly increased cell proliferation and GSH level, while decreased the levels of ROS, MDA, TNF-α, β-GAL and AGEs following DG-induced aging.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2018  |  View Paper
It is known that ethacrynic acid (EA) decreases the intracellular levels of glutathione.
Toxicology and applied pharmacology  •  2015  |  View Paper
Glutathione (GSH) levels were dose-dependently increased in cells treated with EA and this increase was hardly affected by NAC addition.
Cancer science  •  2003  |  View Paper
This implies that ethacrynic acid may modulate drug resistance of tumor cells not only by inhibiting glutathione S-transferase activity, but also by inhibiting the export of drug conjugates from the cell by MRP.
FEBS letters  •  1996  |  View Paper
EA pretreatment resulted in a marked GSH depletion as well as GST activity inhibition in both of these cells.
Archives of biochemistry and biophysics  •  1994  |  View Paper
Treatments with PNBC, IDM, and EA decreased GSH contents in guard cells.
Bioscience, biotechnology, and biochemistry  •  2012  |  View Paper
Herein we show that ethacrynic acid EA ), which is able to increase cellular oxidative stress through glutathione depletion , induces TDP-43 C-terminal phosphorylation at serine 403/404 and 409/410, insolubilization, C-terminal fragmentation, and cytoplasmic distribution in NSC34 cells and primary cortical neurons.
Neurobiology of Disease  •  2012  |  View Paper
In addition, glutathione (1 microm) reversed the prevention achieved by ethacrynic acid and diamide.
Fundamental & clinical pharmacology  •  2005  |  View Paper
Diethyl maleate, ethacrynic acid and buthionine sulfoximine, three agents which significantly reduce glutathione levels , also decreased 99mTc-HMPAO retention in both astrocytes and in neurons.
Brain Research Reviews  •  2001  |  View Paper
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