supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Ethacrynic Acid
supplement:
Diallyl Disulfide
Research Papers that Mention the Interaction
“In contrast, DADS and DATS significantly increased hepatic PGST activity toward ethacrynic acid by 30 and 40%, respectively, as compared with the control rats (P < 0.05).”
Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs.“Hepatocytes isolated from male Sprague-Dawley rats were cultured with 50-200 micromol/L of DAS, DADS, or DATS for 24 h. DADS and DATS increased GST activity toward ethacrynic acid by 40 and 66%, respectively (P < 0.05).”
“To the phase II enzyme, garlic oil, DADS , and DATS significantly increased the glutathione S-transferase (GST) activity toward ethacrynic aicd (P < 0.05).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback