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“Treatment of Caco-2 colon adenocarcinoma cells with all-trans-retinoic acid or 1alpha,25-dihydroxyvitamin D3 also increases 17beta-oestradiol oxidation to oestrone.”
“ RA may directly affect ER level and enhance estrogenic action , resulting in promotion of tumor growth, or it may act independently for tumor growth and elevation of serum GH level.”