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Last Updated: 2 years ago

Possible Interaction: Estrone and Progestins





Research Papers that Mention the Interaction

Obesity may worsen prognosis as a result of increased synthesis of estrogens in peripheral fat and one possible approach to this problem is to use progestins to counteract the estrogenic drive.
Women's health  •  2016  |  View Paper
These progestins , as well as tibolone, can also block the conversion of estrone to estradiol by the inhibition of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD-1).
The Journal of Steroid Biochemistry and Molecular Biology  •  2005  |  View Paper
Various progestins (e.g. promegestone, nomegestrol acetate, medrogestone, 17-deacetyl norgestimate, dydrogesterone and its 20-dihydro derivative), as well as tibolone and its metabolites, have been shown to inhibit estrone sulfatase and 17beta-hydroxysteroid dehydrogenase.
Maturitas  •  2003  |  View Paper
In another series of studies, it was also demonstrated that various progestins are very active in inhibiting the 17 beta-hydroxysteroid dehydrogenase for the conversion of estrone to estradiol.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  1999  |  View Paper
Our results suggest that synthetic progestogens can influence the estrone sulfatase activity measured in human breast carcinoma tissues.
The Journal of Steroid Biochemistry and Molecular Biology  •  1991  |  View Paper
This finding suggests that it is not the individual component alone, but the combined action of estrogenic and progestational components which determines the potency of an oral contraceptive agent.
Contraception  •  1981  |  View Paper
The theory that the side effects of continuous estrogenic exposure can be averted by periodic interruption with progestins is also discussed.
Gynecologic oncology  •  1978  |  View Paper
The progestagen sponge plus 3 beta-HSD inhibitor treatment also caused a significant increase in oestrous cycle duration of approximately 1.5 days.
Journal of reproduction and fertility  •  1987  |  View Paper
The assay of the monoamine oxidase enzyme did not reveal any significant change, though the estrogenic and progestogenic hormones were found to have opposing effects on the enzyme levels.
Biochemical pharmacology  •  1980  |  View Paper
In general progestational effects are antagonized by estrogens and estrogenic effects are inhibited by progestins although certain potentiations are seen.
Acta endocrinologica  •  1967  |  View Paper