Possible Interaction: Estrone and Progesterone

“Plasma steroid concentrations also demonstrated a … of the entire menstrual cycle: progesterone levels were statistically significantly lower in LI than in … cycles and this defect was worse when the estrogenic influence was persistent; the preovulatory estradiol peak was disturbed in … circumstances, as was the concentration of endometrial steroid receptors.”

“Our previous works4,5) have also demonstrated that by enzyme test certain estrogenic and androgenic steroids are capable of inhibiting the progestational activity of progesterone.”

“A study of the action of estrogen and progestogen on the onset, magnitude and duration of responsiveness (sensitivity) of the uterus to traumatization … revealed that, in animals ovariectomized after estrus, maximal sensitivity could not be achieved by injection of progesterone alone, but was observed when both estrone … progesterone were ….”

“In hypophysectomized rats estrone and progesterone , when combined, stimulated the growth of the tumor, and this growth was accelerated by the additional administration of lactogenic or growth hormones.”

“Recently we reported (Meites and Sgouris, 1953) that the ability of a moderate dose of prolactin to initiate milk secretion in rabbits with well developed mammary glands, could be effectively inhibited if optimal, mammary growth-promoting doses of estrone and progesterone were injected at the same time.”

“ Progesterone (2.5 mg) given simultaneously with estrone (25γ) beginning on the 20th day has the sams effect as progesterone alone, preventing the above effects of estrone alone.”

“When progesterone and œstrone were injected concurrently into mice whose pelves had been rendered sensitive to œstrogen, the action of œstrone was much impaired.”

“The production of progesterone in the presence of pregnenolone or estradiol synthesis from androstenedione, estrone or testosterone showed dose- and time-dependent increases.”

“ Estrone levels were significantly higher in type I BCF of patients in the luteal phase compared to both the follicular and postmenopausal type I cysts.”

“Cross-reactivity with estrone and estriol, testosterone, or progesterone is < 0.2%.”