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“The urinary concentrations of nearly all other estrogen metabolites, including levels of estradiol, estrone , estriol, and 16alpha-hydroxyestrone, were lower after I3C treatment.”
Journal of the National Cancer Institute • 1997 | View Paper
“The levels of circulating estrone were increased in response to I3C treatment and were greater in DMBA-initiated rats than in uninitiated rats, which may contribute to the preventive effect of I3C.”