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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estriol
supplement:
Indole-3-Carbinol
Research Papers that Mention the Interaction
“The urinary concentrations of nearly all other estrogen metabolites, including levels of estradiol, estrone, estriol , and 16alpha-hydroxyestrone, were lower after I3C treatment.”
Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans.“Treatment … I3C at 250 mg/kg increased the capacity of liver microsomes to metabolize E2 … 2-OH-E2, 2-OH-E1, 6alpha-OH-E2, 6beta-OH-E2, estriol , and 15alpha-OH-E2, and E1 to 2-OH-E1, 2-…-E2, 6(alpha+beta)-OH-E1, and 6alpha-OH-E2.”
Modulations of P450 mRNA in liver and mammary gland and P450 activities and metabolism of estrogen in liver by treatment of rats with indole-3-carbinol.
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