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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Estradiol and Vitamin K

supplement:

Vitamin K

Research Papers that Mention the Interaction

Subsequent experiments showed that vitamin K2 binds 17beta hydroxysteroid dehydrogenase 4 and decreases the intracellular estradiol :estrone ratio, which resulted in the inhibition of the amount of estrogen receptor alpha-binding to its target DNA.
Life sciences  •  2005  |  View Paper
Combined stimulation with estradiol-17beta and menaquinone 4 (MK4), homologue of vitamin K2, showed a remarkable increase of total TM antigen level only in U937 cells among these leukemic cell lines, whereas a single treatment of each agent showed a modest or a moderate increase.
Seminars in thrombosis and hemostasis  •  1999  |  View Paper
However, the increased estradiol concentration was reduced after the administration of menatetrenone or elcatonin.
Metabolism: clinical and experimental  •  2002  |  View Paper
It is suggested that both the pharmacological dose of vitamin K2 and medical dose of estradiol suppressed the development of arteriosclerosis associated with diabetes mellitus, owing to radical scavenging activity of vitamin K2 and estradiol.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  2000  |  View Paper