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“Changes of estradiol levels during the menstrual cycle correlated positively with the changes of ascorbic acid levels and total antioxidant plasma status (p < 0.05).”
“Furthermore, estradiol levels correlated positively with ascorbic acid levels (p < 0.05, r < 0.5), ascorbic-dehydroascorbic acid ratio (p < 0.05, r < 0.5), and total antioxidant plasma status (p < 0.05, r < 0.8) in all menstrual phases. ”
Acta obstetricia et gynecologica Scandinavica • 2006 | View Paper
“Interestingly, although ascorbic acid (1 mM) increased the recovery of 2- and 4-hydroxy-17 beta-estradiol from microsomal incubations, it decreased the recovery of the methoxy metabolites (approximately 40%).”
Drug metabolism and disposition: the biological fate of chemicals • 1996 | View Paper
“ Estradiol-17-beta decreased ascorbic acid levels and stimulated dehydroascorbatase, while progesterone had no significant effect on ascorbic acid levels or on enzyme activities.”
Advances in experimental medicine and biology • 1986 | View Paper
“ Ascorbic acid decreased binding to proteins and aqueous-soluble fraction with both [3H] estradiol and [3H]epoxyestrenolone in incubations with microsomes but no effect with cytosol fraction.”
Biochemical and biophysical research communications • 1985 | View Paper
“Injecting meat-type chicks implanted with estradiol with 10 mg ascorbic acid daily significantly reduced liver weight, liver lipids, and plasma estradiol, but injecting with 8 mg alpha-tocopherol daily had no significant effect.”
Journal of steroid biochemistry • 1984 | View Paper
“Iodination, thyroxine degradation, and estradiol binding are inhibited by azide, cyanide, aminotriazole, methimazole, ascorbic acid and ergothioneine, all of which can inhibit peroxidase-catalyzed reactions.”