Possible Interaction: Estradiol and Vitamin C

“Changes of estradiol levels during the menstrual cycle correlated positively with the changes of ascorbic acid levels and total antioxidant plasma status (p<0.05).”

“Furthermore, estradiol levels correlated positively with ascorbic acid levels (p<0.05, r<0.5), ascorbic–dehydroascorbic acid ratio (p<0.05, r<0.5), and total antioxidant plasma status (p<0.05, r<0.8) in all menstrual phases.”

“Interestingly, although ascorbic acid (1 mM) increased the recovery of 2- and 4-hydroxy-17 beta-estradiol from microsomal incubations, it decreased the recovery of the methoxy metabolites (approximately 40%).”

“ Ascorbic acid and glutathione inhibited covalent binding of estradiol to macromolecules in the in vitro microsomal system.”

“ Ascorbic acid decreased binding to proteins and aqueous-soluble fraction with both [3H] estradiol and [3H]epoxyestrenolone in incubations with microsomes but no effect with cytosol fraction.”

“Injecting meat-type chicks implanted with estradiol with 10 mg ascorbic acid daily significantly reduced liver weight, liver lipids, and plasma estradiol, but injecting with 8 mg α-tocopherol daily had no significant effect.”

“ Ascorbic acid decreased the general metabolism of estradiol in the hepatocyte incubations but did not decrease irreversible binding to proteins.”

“In male and female rats, oestradiol raises adenohypophyseal weight, the thyroxine-binding capacity of the adenohypophyseal proteins and the blood ceruloplasmin (polyphenol oxidase) level and reduces the ascorbic acid concentration in the hypothalamus.”

“ 17β-Estradiol and progesterone also inhibit the transport of ascorbic acid and, in their presence, corticosteroid production is increased.”