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Possible Interaction: Estradiol and Vitamin C


Vitamin C

Research Papers that Mention the Interaction

Changes of estradiol levels during the menstrual cycle correlated positively with the changes of ascorbic acid levels and total antioxidant plasma status (p < 0.05).
Furthermore, estradiol levels correlated positively with ascorbic acid levels (p < 0.05, r < 0.5), ascorbic-dehydroascorbic acid ratio (p < 0.05, r < 0.5), and total antioxidant plasma status (p < 0.05, r < 0.8) in all menstrual phases.
Acta obstetricia et gynecologica Scandinavica  •  2006  |  View Paper
Interestingly, although ascorbic acid (1 mM) increased the recovery of 2- and 4-hydroxy-17 beta-estradiol from microsomal incubations, it decreased the recovery of the methoxy metabolites (approximately 40%).
Drug metabolism and disposition: the biological fate of chemicals  •  1996  |  View Paper
Estradiol-17-beta decreased ascorbic acid levels and stimulated dehydroascorbatase, while progesterone had no significant effect on ascorbic acid levels or on enzyme activities.
Veterinary and human toxicology  •  1993  |  View Paper
Ascorbic acid and glutathione inhibited covalent binding of estradiol to macromolecules in the in vitro microsomal system.
Advances in experimental medicine and biology  •  1986  |  View Paper
Ascorbic acid decreased binding to proteins and aqueous-soluble fraction with both [3H] estradiol and [3H]epoxyestrenolone in incubations with microsomes but no effect with cytosol fraction.
Biochemical and biophysical research communications  •  1985  |  View Paper
Injecting meat-type chicks implanted with estradiol with 10 mg ascorbic acid daily significantly reduced liver weight, liver lipids, and plasma estradiol, but injecting with 8 mg alpha-tocopherol daily had no significant effect.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1985  |  View Paper
Ascorbic acid decreased the general metabolism of estradiol in the hepatocyte incubations but did not decrease irreversible binding to proteins.
Journal of steroid biochemistry  •  1984  |  View Paper
Iodination, thyroxine degradation, and estradiol binding are inhibited by azide, cyanide, aminotriazole, methimazole, ascorbic acid and ergothioneine, all of which can inhibit peroxidase-catalyzed reactions.
The Journal of experimental medicine  •  1979  |  View Paper