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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estradiol
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“Treatment with 100 or 300 mM PL resulted in dose-dependent decreases in total cell numbers in the absence (26-85% and 72-98%, respectively) and presence (38-42% and 88-98%, respectively) of estradiol in all cell lines studied compared with control cells cultured without PL supplementation.”
Pyridoxal Supplementation Reduces Cell Proliferation and DNA Synthesis in Estrogen-Dependent and -IndependentMammary Carcinoma Cell Lines“ Vitamin B6 deficient female rats showed a significantly earlier, greater and more prolonged uptake of a tracer dose of [3H]oestradiol into the uterus, with increased nuclear accumulation, compared with vitamin B6 supplemented animals.”
Increased uterine uptake and nuclear retention of [3H]oestradiol through the oestrous cycle and enhanced end-organ sensitivity to oestrogen stimulation in vitamin B6 deficient rats.“Thus pyridoxal phosphate PLP ) may modulate OAT activity in rat kidney through the action of estradiol.”
“In animals which … dose of vitamin B6, … oestradiol led to further reduction in the production of 14CO2 from [ring-2-14C]tryptophan, suggesting a further reduction in the activity … an increase in the production of 14CO2 from [methylen-14C]tryptophan, but with a delay in the peak of production.”
“There were significant inverse correlations between the uptake of oestradiol into target tissues and vitamin B6 nutritional status as determined by the concentrations of pyridoxal phosphate in plasma and liver.”
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