Possible Interaction: Estradiol and Selenium

“suppressed estradiol levels to a mean 36.3 +/- 3.3% ( SE ) (n = 14) of base line after 4 to 7 days and maintained this suppression in six of seven patients for greater than 14 days.”

“Additionally, treatment of the cells with 5 ng/mL selenium significantly ameliorated the levels of estradiol , which were decreased in response to heat exposure.”

“ Se … estradiol (E2) production, which could be, at least partially, due to increased levels of 3β-hydroxysteroid dehydrogenase(3β-HSD), steroidogenic acute regulatory protein (StAR), p-… monophosphate (cAMP) (P < 0.05); however, follicle-stimulating hormone (FSH) significantly enhanced the production of E2, progesterone (P4) and cAMP (P < 0.05).”

“ Selenium was also able to increase the plasma levels of LH, FSH, and estradiol toward the control level.”

“The mitotic index of cultured alpha-cells was significantly decreased [by 67 +/- 5% SE )] 48 h after the addition of estradiol to the culture medium.”

“ Estradiol significantly decreased the Bmax from 359.7 ± 23.0 fmol/mg protein (mean ± SE ) in ovariectomized rats to 246.2 ± 19.0 fmol/mg protein with the 5 μg/kg dose and to 179.3 ±10.1 fmol/mg protein with the 25 μg/kg dose.”

“The selenium-containing estrogens retained the ability to displace [3H]estradiol from the estrogen receptor of rabbit uterine cytosol, although in most instances the displacement was small (3-7% compared to estradiol).”