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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estradiol
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Suboptimal doses of resveratrol and estradiol were additive.”
“While less potent than estradiol, which displays maximal effects at doses of 0.1 nmol/l, the maximal activation induced by resveratrol was several-fold higher than with estradiol.”
“Because resveratrol inhibits CYP450 and is an estrogen-receptor-alpha antagonist, resveratrol may abrogate the antimitogenic effects of estradiol.”
“Treatment of MCF-7 and T47D cells with RSV (10(-6) M) caused stimulation of precursor IGF-II mRNA and protein; this effect was blocked by coincubation with 17beta-estradiol (10(-9) M).”
“Treatment of MCF-7 cells with resveratrol in the presence of 17β-oestradiol (E2) further enhanced MAPK activation, but E2 blocked resveratrol-induced apoptosis, as measured by nucleosome ELISA and DNA fragmentation assays.”
“At 10(-5) M, resveratrol maximally inhibited the growth stimulatory effect mediated by 10(-9) M estradiol without affecting cell viability.”
“At the molecular level, resveratrol in a dose-dependent fashion antagonized the stimulation by estradiol of an estrogen response element reporter gene construct and of progesterone receptor gene expression in MCF-7 cells.”
Effect of resveratrol on the expression of autocrine growth modulators in human breast cancer cells.“In vitro radiation survival experiment showed that the radioprotection activity of resveratrol (D0 = 3.18 Gy) is stronger than that of estradiol (D0 = 2.59 Gy).”
“… RSV … estradiol level and NEP level and that may have a great role to decrease Aβ deposition as it has been confirmed that there is a … NEP level, and by increasing the NEP level in brain, this lead to decrease in Aβ deposition and enhancing its degradation by NEP.”
Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease.“Resveratrol-mediated decrease in proliferation was reversed by cotreatment with ICI 182,780, and resveratrol effectively competed with 17β-estradiol for binding to the ER, exhibiting an IC50 of 8.92 ± 0.14 μM. Resveratrol induced a sustained increase in ER-dependent NO production.”
“But in contrast, resveratrol with hydroxy groups at positions 4, 3', and 5' as well as methoxy substituted stilbene derivatives and 17beta-estradiol were ineffective.”
“ 17Beta-estradiol significantly lowered serum cholesterol, and this response was antagonized by cotreatment with resveratrol.”
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