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Last Updated: 2 years ago

Possible Interaction: Estradiol and Resveratrol

supplement:

Resveratrol

Research Papers that Mention the Interaction

Suboptimal doses of resveratrol and estradiol were additive.
While less potent than estradiol, which displays maximal effects at doses of 0.1 nmol/l, the maximal activation induced by resveratrol was several-fold higher than with estradiol.
European journal of endocrinology  •  1998  |  View Paper
Because resveratrol inhibits CYP450 and is an estrogen-receptor-alpha antagonist, resveratrol may abrogate the antimitogenic effects of estradiol.
The Journal of clinical endocrinology and metabolism  •  2010  |  View Paper
Treatment of MCF-7 and T47D cells with RSV (10(-6) M) caused stimulation of precursor IGF-II mRNA and protein; this effect was blocked by coincubation with 17beta-estradiol (10(-9) M).
Endocrinology  •  2005  |  View Paper
Treatment of MCF-7 cells with resveratrol in the presence of 17β-oestradiol (E2) further enhanced MAPK activation, but E2 blocked resveratrol-induced apoptosis, as measured by nucleosome ELISA and DNA fragmentation assays.
British Journal of Cancer  •  2004  |  View Paper
At 10(-5) M, resveratrol maximally inhibited the growth stimulatory effect mediated by 10(-9) M estradiol without affecting cell viability.
At the molecular level, resveratrol in a dose-dependent fashion antagonized the stimulation by estradiol of an estrogen response element reporter gene construct and of progesterone receptor gene expression in MCF-7 cells.
Antioxidants & redox signaling  •  2001  |  View Paper
In vitro radiation survival experiment showed that the radioprotection activity of resveratrol (D0 = 3.18 Gy) is stronger than that of estradiol (D0 = 2.59 Gy).
Yao xue xue bao = Acta pharmaceutica Sinica  •  2000  |  View Paper
RSV … estradiol level and NEP level and that may have a great role to decrease Aβ deposition as it has been confirmed that there is a … NEP level, and by increasing the NEP level in brain, this lead to decrease in Aβ deposition and enhancing its degradation by NEP.
Advances in experimental medicine and biology  •  2015  |  View Paper
Resveratrol-mediated decrease in proliferation was reversed by cotreatment with ICI 182,780, and resveratrol effectively competed with 17β-estradiol for binding to the ER, exhibiting an IC50 of 8.92 ± 0.14 μM. Resveratrol induced a sustained increase in ER-dependent NO production.
Journal of cardiovascular pharmacology  •  2007  |  View Paper
But in contrast, resveratrol with hydroxy groups at positions 4, 3', and 5' as well as methoxy substituted stilbene derivatives and 17beta-estradiol were ineffective.
European journal of pharmacology  •  2003  |  View Paper
17Beta-estradiol significantly lowered serum cholesterol, and this response was antagonized by cotreatment with resveratrol.
Endocrinology  •  1999  |  View Paper
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