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Possible Interaction: Estradiol and Resveratrol

supplement:

Resveratrol

Research Papers that Mention the Interaction

Because resveratrol inhibits CYP450 and is an estrogen-receptor-alpha antagonist, resveratrol may abrogate the antimitogenic effects of estradiol.
Because resveratrol inhibits CYP450 and is an estrogen-receptor-alpha antagonist, resveratrol may abrogate the antimitogenic effects of estradiol.
CONCLUSION In conclusion, dietarily relevant levels of resveratrol abrogate the antimitogenic effects of estradiol by inhibiting CYP450-mediated estradiol metabolism and blocking estrogen receptor-alpha.
CONCLUSION In conclusion, dietarily relevant levels of resveratrol abrogate the antimitogenic effects of estradiol by inhibiting CYP450-mediated estradiol metabolism and blocking estrogen receptor-alpha.
METHODS AND RESULTS In human female coronary VSMCs, resveratrol (0.1-10 microm) alone did not influence serum-induced DNA or collagen synthesis or cell proliferation or migration; however, resveratrol abrogated the inhibitory effects of estradiol , but not 2-hydroxyestradiol or 2-methoxyestradiol, on these responses.
METHODS AND RESULTS In human female coronary VSMCs, resveratrol (0.1-10 microm) alone did not influence serum-induced DNA or collagen synthesis or cell proliferation or migration; however, resveratrol abrogated the inhibitory effects of estradiol , but not 2-hydroxyestradiol or 2-methoxyestradiol, on these responses.
Resveratrol also abrogated the inhibitory effects of estradiol on positive growth regulators (cyclin A, cyclin D, MAPK phosphorylation) and the stimulatory effects of estradiol on negative growth regulators (p21, p27).
The Journal of clinical endocrinology and metabolism  •  2010  |  View Paper
Resveratrol decreased estrogen metabolism and blocked formation of DNA adducts in cells treated with TCDD and/or estradiol.
Cancer Prevention Research  •  2008  |  View Paper
Resveratrol inhibited the growth of estrogen receptor-positive MCF-7 cells cultivated in the presence of estradiol in a dose-dependent fashion.
Antioxidants & redox signaling  •  2001  |  View Paper
In vitro radiation survival experiment showed that the radioprotection activity of resveratrol (D0 = 3.18 Gy) is stronger than that of estradiol (D0 = 2.59 Gy).
In vitro radiation survival experiment showed that the radioprotection activity of resveratrol (D0 = 3.18 Gy) is stronger than that of estradiol (D0 = 2.59 Gy).
Yao xue xue bao = Acta pharmaceutica Sinica  •  2000  |  View Paper
In contrast, medium concentrations of (E)-resveratrol (10 and 25 microM) and (Z)-resveratrol (25 microM) functioned as superagonists of estradiol.
Life sciences  •  2000  |  View Paper
Suboptimal doses of resveratrol and estradiol were additive.
While less potent than estradiol, which displays maximal effects at doses of 0.1 nmol/l, the maximal activation induced by resveratrol was several-fold higher than with estradiol.
European journal of endocrinology  •  1998  |  View Paper
RSV … estradiol level and NEP level and that may have a great role to decrease Aβ deposition as it has been confirmed that there is a … NEP level, and by increasing the NEP level in brain, this lead to decrease in Aβ deposition and enhancing its degradation by NEP.
Advances in experimental medicine and biology  •  2015  |  View Paper