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Possible Interaction: Estradiol and Quercetin



Research Papers that Mention the Interaction

Comparing the areas under the curve, the antioxidant effect of quercetin was 8 times higher than the one observed with estradiol (p < 0.01).
Estradiol and quercetin showed additive antioxidant activity.
Climacteric : the journal of the International Menopause Society  •  2004  |  View Paper
The inhibitory effects of estradiol were blocked by the COMT inhibitors OR486 and quercetin.
Hypertension  •  2003  |  View Paper
The growth inhibitory effects of estradiol were also blocked by quercetin (10 micromol/L) and OR 486 (10 micromol/L) inhibitors of catechol-O-methyltransferase (converts catecholestradiols to methoxyestradiols).
Hypertension  •  2002  |  View Paper
This hypothesis was confirmed by in vivo studies which demonstrated that injection of luteolin or quercetin blocked estradiol stimulation of nuclear type II sites in the immature rat uterus and this correlated with an inhibition of uterine growth (wet and dry weight).
Journal of steroid biochemistry  •  1988  |  View Paper
Co-administration of quercetin with E caused uterine fluid secretion rate, Na+, Cl- and HCO3- concentrations to decrease.
PloS one  •  2017  |  View Paper
Moreover, the inhibitory effects of estradiol were blocked by the CYP450 inhibitor 1-aminobenzotriazole (10 micromol/L) and the COMT inhibitors quercetin (10 micromol/L) and OR486 (10 micromol/L).
Hypertension  •  2002  |  View Paper
Similarly, several flavonoids (naringenin, hesperetin, kaempferol, quercetin , rutin, flavone, alpha-naphthoflavone and beta-naphthoflavone) also inhibited rat liver microsomal glucuronidation of estrone and estradiol to varying degrees.
The Journal of Steroid Biochemistry and Molecular Biology  •  1998  |  View Paper
In animals treated with two 10-mg estradiol implants, quercetin also decreased by 63-65% the urinary excretion of 2- and 4-hydroxyestradiol monomethyl ethers.
The accumulation of 2- and 4-hydroxyestradiol during co-administration of estradiol and quercetin may enhance metabolic redox cycling of catecholestrogens and thus estradiol-induced kidney tumorigenesis.
The Journal of Biological Chemistry  •  1996  |  View Paper
Combined treatment of estradiol plus 3% quercetin decreased the rates of kidney catechol-O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by 34 and 22%, respectively, from values obtained with hormone treatment alone.
The coadministration of estradiol plus 0.3 or 3% quercetin for 16 days increased renal NADPH-dependent estradiol-4- but not estradiol-2-hydroxylase activities by 91 or 73%, respectively, over values obtained with hormone treatment alone.
The coadministration of estradiol plus 3% quercetin significantly (p < 0.05) increased the mean number of large tumor nodules and the incidence of abdominal metastases over values obtained with hormone treatment alone.
Toxicology and applied pharmacology  •  1994  |  View Paper