Possible Interaction: Estradiol and Proline

“Further, estradiol prevented okadaic acid‐induced hyperphosphorylation of tau in both proline‐ and non‐proline‐directed sites, and antiestrogens blocked this effect.”

“Additionally, the induction of a massive NO/GnRH … rat treated with estradiol benzoate strongly suggested that estradiol is participating in the stimulation … between diestrus II and PRO : The present study is the first demonstrating that ME can spontaneously … NO's rhythm of secretion varies markedly across the estrous cycle.”

“ Estradiol-17beta demonstrated a time- and dose-dependent reduction of proline transport; at 10-6M, transport of proline was decreased by 50 percent.”

“Administration of estradiol valerate decreased the entry of proline into tumor cells from intact, diabetic, or ovariectomized animals; the response to the steroid hormone was greater in ovariectomized or diabetic rats compared to intact animals.”

“The wet weight and the dry, defatted weight of metaphyseal bone were increased by estradiol and the specific activity of hydroxyproline in collagen and proline in the noncollagenous protein was increased.”