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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Whole‐cell voltage‐clamp revealed that estradiol affected the amplitude, decay time, and the voltage dependence of A‐type potassium currents in GnRH neurons.”
Steroid Regulation of GnRH Neurons“ Estradiol reduced both potassium current in the membrane potential range typically achieved during response to fast synaptic inputs and membrane capacitance.”
Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents“ Estradiol alters two components of potassium currents in these cells: a transient current, IA, and a sustained current, IK.”
“As potassium channels play a crucial role in cell excitability, we hypothesized that 17beta-estradiol caused excitability by modulating potassium flux through the neuronal cell membrane.”
“In the same artery segment, 17beta-estradiol induced a significant decrease in the relative ratio between the repeated contractile response to potassium 30 and 120 mM (100+/-7% vs. 132+/-11%, p<0.05).”
“The antiarrhythmic effect of estradiol may be caused by its action on potassium current.”
“Calcium (P less than 0.05), chloride (P less than 0.05) and potassium (P less than 0.01) were increased in response to oestradiol.”
“The data indicate that 17beta-estradiol reduces the renal excretion of sodium and potassium primarily as a consequence of a reduction in food intake and exerts no specific effect on either sodium or potassium metabolism.”
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