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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Estradiol
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“In this study, treatment of steroid-starved ERα-positive MCF-7 and T47D mammary carcinoma cells with 17β-estradiol resulted in increased cellular uptake of the PUFA arachidonic acid (AA) and eicosapentaenoic acid (EPA), important building blocks for cellular membranes, and increased ACSL4 protein levels.”
17&bgr;-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells“After energy intake was adjusted for, the ratio of polyunsaturated to saturated fat (P:S) in the diet was significantly inversely associated with plasma estradiol and estrone during the luteal phase of the menstrual cycle.”
“Furthermore, diet enriched with longer chain n-3 PUFA increased the maternal plasma concentration of progesterone and estradiol during pregnancy (P < 0.05), which coincides with an increase in the number of fetuses sustained till day 18.5.”
A low-fat diet enriched in fish oil increased lipogenesis and fetal outcome of C57BL/6 mice.“ Estradiol increased 22:5n-3 and total n-3 polyunsaturated fatty acids ( PUFA ) in intact, and decreased 18:2n-6 in BCO rats.”
“RESULTS Maternal intake of n-3 PU A di ets significantly increased pregnancy 17 bet a-estradiol (E 2) levels (48% increase when compared with high n-6 PUFA diet; P < 0.0045).”
“With any of the two types of microsomal membranes used, the results show that estradiol is more susceptible to be esterified to polyunsaturated fatty acids than saturated ones.”
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