Possible Interaction: Estradiol and Methionine

“We have shown previously that estradiol regulates the synthesis of a M r 24,000 protein, of unknown function, in the human breast cancer cell line MCF-7.”

“The average increase in gene expression after 10−9 M estradiol treatment was 8.5-fold for CXCL10 and 7.7-fold for CXCL11 compared with medium alone.”

“In equimolar combinations of MPA and estradiol , proliferation of the cells was significantly stimulated at the concentrations 10−6 and 10−5 M by 26% and 44%, respectively.”

“ Estradiol concentrations were significantly higher in M women (p =.0001; M, 125.0 +/- 20.8 pg/mL, P, 54.6 +/- 38.6 pg/mL, PM, 46.2 +/- 34.6 pg/mL).”

“The steroids progesterone, 17β-estradiol , and estrone inhibit 18–54,SF cell growth approximately 75% at concentrations of 3.2 × 10-6, 1.8 × 10-6, and 3 × 10-6 M , respectively.”

“Data are herein reported which suggest a-estradiol , some of its esters, and estrone in a concentration of 5 × 10−5 M inhibit oxidation of substrates whose oxidative systems are coenzyme linked but do not inhibit the succinoxidase system.”

“Plane of nutrition did not affect transcript profiles at 10 wk of age, but estradiol supplementation decreased MET and WNT7A transcript abundance.”

“ Estradiol valerate decreased uterine FGF7 (fibroblast growth factor 7) and MET (hepatocyte growth factor receptor) expression and increased INHBA (inhibin βA).”

“During 2 weeks of culture, estradiol at the high concentration of 10−5 M blocked the androgenic activation of [3H]thymidine incorporation into DNA.”

“ Estradiol-17beta demonstrated a time- and dose-dependent reduction of proline transport; at 10-6 M , transport of proline was decreased by 50 percent.”