Effects of six months melatonin treatment on sleep quality and serum concentrations of estradiol, cortisol, dehydroepiandrosterone sulfate, and somatomedin C in elderly women.

 concentrations was observed after 6 months of the 

 treatment in comparison to initial levels.

The effect of estradiol on the production of melatonin in postmenopausal women.

 treatment led to an increase as well as decrease of 

A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers

 levels in our study population may have hindered the ability to detect any further estradiol-lowering effects of 

Circulating melatonin and the risk of breast and endometrial cancer in women.

Of particular relevance to breast cancer risk,

 may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces 

Membrane‐bound melatonin receptor MT1 down‐regulates estrogen responsive genes in breast cancer cells

Melatonin–estrogen interactions in breast cancer

Hormonal interactions in human prostate tumor LNCaP cells

 also inhibited 3H-thymidine incorporation and its effects were additive to those of 

Suppression of DNA content was observed in cells treated for 2 days with

 (0.1 nM); this suppression was maintained for longer periods in the presence than in the absence of 

Melatonin blocks the activation of estrogen receptor for DNA binding

 interferes with the activation of estrogen receptor by 

Plasma Melatonin Profile and Hormonal Interactions in the Menstrual Cycles of Anovulatory Infertile Women Treated with Gonadotropins

 during the follicular phase (r=-0.5180, p < 0.05) and positively with LH (5 + 0.6321, p < 0.05) in the luteal phase, respectively.

Decreased nocturnal melatonin secretion in patients with Klinefelter's syndrome

The results suggest that the suppression of

 secretion in these patients is mediated by GnRH (either directly or indirectly) and/or 

Amplification of nocturnal melatonin secretion in women with functional secondary amenorrhoea: relation to endogenous oestrogen concentration.

There were significant negative correlations between cummulative

 (r = -0.561, p < 0.01) and between peak serum melatonin values and the serum 17 beta-oestradiol (r = -0.608, P < 0.01) in SA.

Interaction between melatonin and estradiol on morphological and morphometric features of MCF‐7 human breast cancer cells

 has been shown to have a direct inhibitory effect on the proliferation of estrogen-responsive MCF-7 human breast cancer cells, involving an interaction with 

Effects of melatonin on the cell cycle kinetics and “estrogen‐rescue” of MCF‐7 human breast cancer cells in culture

 (10(-5)M) was prevented by the simultaneous treatment of the cells with 

 (10(-8)M) in clonogenic soft agar culture, or reversed by the addition of estradiol to cells previously incubated with and inhibited by melatonin (10(-9)M) in monolayer culture.

Relationship between adenohypophyseal and steroid hormones and variations in serum and urinary melatonin levels during the ovarian cycle, perimenopause and menopause in healthy women.

 in the follicular phase, while in the luteal phase a negative correlation was found between melatonin, progesterone and estradiol.

Plasma Levels of Immunoreactive Melatonin, Estradiol, Progesterone, Follicle Stimulating Hormone, and β‐Human Chorionic Gonadotropin During Pregnancy and Shortly After Parturition in Humans

In the pregnant females, there were significant negative correlations between

, melatonin and progesterone, beta hCG and progesterone, and beta hCG and estradiol, and positive correlations between melatonin and FSH and progesterone and estradiol.

Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of rapamycin pathway

 significantly increased the levels of the antioxidant enzymes superoxide dismutase …, IgG, and IgM) (P < 0.05) and the reproductive hormones 

 and luteinizing hormone (P < 0.01) in the plasma and also increased the numbers … level of reactive oxygen species in plasma (P < 0.01) in laying hens.

Melatonin activity and receptor expression in endometrial tissue and endometriosis.

 (1.0 nM)-induced endometrial epithelial cell proliferation at 48 hours but not 24 hours of culture.

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers

 through the control of the enzymes involved in its synthesis, acting as a selective estrogen enzyme modulator (SEEM).

The protective role of melatonin in cadmium-induced proliferation of ovarian cancer cells

The effects of melatonin on bovine uniparental embryos development in vitro and the hormone secretion of COCs

 significantly promoted the secretion of progesterone and 

Melatonin and mammary cancer: a short review.

, at a physiological concentration (1 nM) and in the presence of serum or estradiol: (a) inhibits, in a … cell cycle, and (c) reduces the metastasic capacity of these cells and counteracts the stimulatory effect of 

 on cell invasiveness; this effect is … E-cadherin and beta(1)-integrin.

Melatonin blocks the stimulatory effects of prolactin on human breast cancer cell growth in culture.

 (aMT) appears to be a potentially important oncostatic substance that can block the mitogenic effects of tumour-promoting hormones and growth factors such as 

Effects of melatonin on the synthesis of estradiol and gene expression in pig granulosa cells

Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats.

 benzoate-induced endometrial hyperplasia and prevented the occurrence of atypia associated with a significant reduction in lipid peroxide level and NF-κB mRNA and a significant rise in immune-expression of caspase-3, interleukin-2 (IL-2) mRNA and total antioxidant levels in uterine tissues.

Melatonin mitigates bisphenol A-induced estradiol production and proliferation by porcine ovarian granulosa cells in vitro.

 co-incubation reduced the high levels of 

 in porcine ovarian granulosa cells induced by BPA stimulation.

Melatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms

However, pre-, simultaneous, or posttreatment of lead-exposed rats with

 but dose-dependently increased other parameters.

The effect of exogenous melatonin during the non-reproductive season on the seminal plasma hormonal profile and the antioxidant defence system of Rasa Aragonesa rams.

 levels significantly (P<0.05) increased four and eight weeks after 

Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen‐deficient female rats: the impact of circulating estrogen on its hormetic dose–response

These results demonstrate complex interactions and synergistic antioxidant, radical-scavenging, and anti-inflammatory actions between

, and highlight the potential need to rectify the melatonin's hormetic dose-response by the level of circulating estradiol in the treatment of female stroke patients.

Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid dehydrogenase activity and expression in glioma cells.

 at the estrogen receptor level in different kinds of neoplasias and also regulates the expression and the activity of some enzymes involved in the biosynthesis of estrogens in peripheral tissues.

Melatonin Activates Brain Dopaminergic Systems in the Eel with an Inhibitory Impact on Reproductive Function

Concerning the pituitary-gonad axis, we showed that

 treatment decreased both gonadotrophin beta-subunit (LHbeta, FSHbeta) mRNA expression and reduced sexual steroid (11-ketotestosterone, 

Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats.

 (not modified by melatonin) with the positive effects of 

 (improvement of sleep quality, prevention of breast cancer, etc.).

A biphasic effect of estradiol on serotonin metabolism in rat pineal organ cultures

 (1 nM) significantly increased serotonin, conversion to 

 and 5-methoxytryptophol by rat pineal glands in organ culture whereas larger, pharmacological, doses (i.e. 1000 nM) impaired it significantly.

Pineal melatonin inhibition of tumor promotion in theN-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo

 appears to be an antipromoting hormone that may antagonize the tumor-promoting actions of 

Inhibition of the basal and oestradiol-stimulated mitotic activity of primary spermatogonia by melatonin in the testis of the frog, Rana esculenta, in vivo and in vitro.

In addition, in short-term cultured testes,

 (at physiological concentration) interferes with the effects of 

 on spermatogonial proliferation, supporting the hypothesis that melatonin exerts the inhibitory effect directly via its local action on the frog gonads.

Melatonin increases oestradiol‐induced bone formation in ovariectomized rats

Serum phosphorus levels decreased after melatonin administration and were augmented after oestradiol injection; overall,

 impaired the increase of serum phosphorus caused by 

 to counteract ovariectomy-induced bone resorption was increased by 

Effect of melatonin on daily LH secretion in intact and ovariectomized ewes during the breeding season.

 seems to be positively linked with the action of 

Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish

 (E(2)) enhanced both activities, which were significantly inhibited and brought down … level of the controls when co-incubated with E(2) and 

 (TRACP at 6 hr: 10(-9) to 10(-5) m; ALP at … hr: 10(-7) m; ALP at 18 hr: 10(-8) m).

Control of ovarian follicles activity in the ewe.

In vitro, FGA blocked aromatization ability, and

, but a further treatment with eCG partly restores the steroid secretion.

Effect of exogenous melatonin on neuroendocrine-reproductive function of middle-aged female rats.

 concentrations were significantly higher on the morning of pro-oestrus in 

New insights into melatonin regulation of cancer growth.

 inhibits the mitogenic action of a number of growth factors including 

 (E2), prolactin (PRL) and epidermal growth factor (EGF), on cancer cell proliferation in vitro (1).

Prenatal melatonin exposure influences the maturation of gonadotropin and prolactin estradiol-benzoate feedback system

 administration altered gonadotropin and prolactin response to 

 inducing precocious sensitivity during prepubertal period but depressed response during the pubertal period.

Estrogenic effects on urinary 6‐sulphatoxymelatonin excretion in the female rat

 production in adult rats, and that the changing pattern of aMT.6S excretion throughout the estrous cycle may provide a basis for a functional relationship between pineal activity and reproduction in this species.

Influence of melatonin and oestradiol on the opioidergic regulation of LH and prolactin release in pony mares.

This opioid inhibition of LH secretion is enhanced by

 for 20 days, again a significant (P < 0.05) LH release in response to naloxone occurred.

Day-night differences in the effects of gonadal hormones on melatonin release from perifused rat pineals. Evidence of a circadian control

 release by glands removed during the dark span and not during the light span.

Effects of melatonin on estrogen receptor expression in the forebrain of outbred (Lak.LVG) golden hamsters

 has direct inhibitory effects on both hypothalamic and pituitary functions, which are also exquisitely sensitive to the feedback effects of 

Detection of estrogen receptor mRNA in trout pineal and retina: estradiol-17 beta modulates melatonin production by cultured pineal photoreceptor cells.

, at concentrations ranging from 10(-10) to 10(-5) mol/liter, a high amplitude rhythm in 

 secretion returned more rapidly than in controls.

The present results suggest that estradiol-17 beta receptors are expressed in the fish pineal and retina and that

 secretion by cultured pineal photoreceptors.(ABSTRACT TRUNCATED AT 250 WORDS)

 during the dark phase of ….e., for 12 hr) affected 

 release in a dose-dependent manner; low concentrations (10(-10) to 10(-8) mol/liter) were inhibitory, whereas … 10(-7) mol/liter) were stimulatory (when compared to the values obtained at 10(-9) mol/liter).

[Photoreceptor cells of the pineal body in culture: effect of 17 beta-estradiol on the production of melatonin].

 during the dark phase of a LD cycle (i.e., for 12 h) affected 

 release in a dose-dependent manner: low concentrations (10(-10) to 10(-8) mol/l) were inhibitory whereas high concentrations (over 10(-7) mol/l) were stimulatory.

, at the concentrations of 10(-9) and 10(-6) mol/l, a high amplitude rhythm in 

 secretion was recovered faster, when compared to controls.

The present results bring the first evidence that

 secretion by cultured pineal photoreceptors.

Melatonin Effects on Prolactin Secretion in Pituitary‐Grafted Male Rats

Regulation of melatonin's activity in the female rat brain by estradiol: effects on neurotransmitter release and on iodomelatonin binding sites.

 to inhibit dopamine release from the hypothalami of intact rats at proestrus.

 directly modulates the responses of the dopaminergic neurosecretory system in the hypothalamus to 

In Vitro Effects of Estradiol, Testosterone, and Progesterone on 5‐Methoxyindole Content, Cyclic Adenosine 3′,5′‐Monophosphate Synthesis, and Norepinephrine Release in Different Parts of the Female Guinea Pig Pineal Complex

These results suggest that physiological concentrations of

 may exert a postsynaptic stimulation of cyclic AMP and 

 synthesis to the same extent in all three regions of the female guinea pig pineal complex.

Effect of varying photoperiods on mammary morphology, DNA synthesis, and hormone profile in female rats.

 in such a model caused a significant decrease in both Prl and 17 

 (E2) levels as well as in the morphologic and DNA synthetic pattern of the mammary gland.

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Possible Interaction: Estradiol and Melatonin

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Research Papers that Mention the Interaction