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“Of particular relevance to breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol.”
“ Estradiol also inhibited 3H-thymidine incorporation and its effects were additive to those of melatonin.”
“Suppression of DNA content was observed in cells treated for 2 days with melatonin (0.1 nM); this suppression was maintained for longer periods in the presence than in the absence of estradiol.”
FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1999 | View Paper
“ Melatonin correlated negatively with estradiol during the follicular phase (r=-0.5180, p < 0.05) and positively with LH (5 + 0.6321, p < 0.05) in the luteal phase, respectively.”
Gynecologic and Obstetric Investigation • 1998 | View Paper
“The results suggest that the suppression of melatonin secretion in these patients is mediated by GnRH (either directly or indirectly) and/or oestradiol.”