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Last Updated: 2 months ago

Possible Interaction: Estradiol and Melatonin



Research Papers that Mention the Interaction

A significant decrease of estradiol concentrations was observed after 6 months of the melatonin treatment in comparison to initial levels.
Neuro endocrinology letters  •  2002  |  View Paper
Both transdermal and oral estradiol treatment led to an increase as well as decrease of melatonin production in different patients.
International journal of clinical pharmacology and therapeutics  •  1995  |  View Paper
Low baseline estradiol levels in our study population may have hindered the ability to detect any further estradiol-lowering effects of melatonin.
Cancer Causes & Control  •  2012  |  View Paper
Of particular relevance to breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol.
Cancer letters  •  2009  |  View Paper
Treatment of the stimulated cells with melatonin counteracted the increase induced by estradiol almost completely.
Journal of pineal research  •  2009  |  View Paper
Furthermore, melatonin decreases circulating levels of estradiol.
Journal of pineal research  •  2005  |  View Paper
Estradiol also inhibited 3H-thymidine incorporation and its effects were additive to those of melatonin.
Suppression of DNA content was observed in cells treated for 2 days with melatonin (0.1 nM); this suppression was maintained for longer periods in the presence than in the absence of estradiol.
The Journal of Steroid Biochemistry and Molecular Biology  •  1999  |  View Paper
Together, these results demonstrate that melatonin interferes with the activation of estrogen receptor by estradiol.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1999  |  View Paper
Melatonin correlated negatively with estradiol during the follicular phase (r=-0.5180, p < 0.05) and positively with LH (5 + 0.6321, p < 0.05) in the luteal phase, respectively.
Gynecologic and Obstetric Investigation  •  1998  |  View Paper
The results suggest that the suppression of melatonin secretion in these patients is mediated by GnRH (either directly or indirectly) and/or oestradiol.
Clinical endocrinology  •  1996  |  View Paper
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