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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Estradiol
supplement:
Long Chain Fatty Acid
Research Papers that Mention the Interaction
“ 17β-estradiol could significantly inhibit the expression of gga-miR-221-5p but promote the expression of ELOVL6 and SQLE genes.”
“Meanwhile, 17β-estradiol could repress the expression of gga-miR-221-5p but increase the expression of ELOVL6 and SQLE, therefore promoting the synthesis of intracellular triglyceride and cholesterol levels in the liver of egg-laying chicken.”
Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver“In addition, estradiol inhibited hypothalamic expression of carnitine palmitoyltransferase (CPT1a and CPT1c) and pyruvate dehydrogenase kinase 4 (PDK4), effects that would be expected to enhance the accumulation of long-chain fatty acids and glycolysis.”
“This enzyme catalyzes the esterification of estradiol with long-chain fatty acids in both liver and extrahepatic tissues.”
“ Long chain fatty acids were known to interfere with the binding between rat uterine estrogen receptors and estradiol.”
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