Possible Interaction: Estradiol and Leucine

“ Oestradiol at a concentration of 10 nmol l-1 increased the incorporation of both [3H]thymidine and [3H]leucine but the differences were significantly different from control only for [3H]leucine incorporation.”

“The uptake of uridine and leucine is also stimulated by estradiol in a dose-related manner.”

“ Estradiol was significantly (P less than 0.02) lower in lactating women ( L , 78 +/- 23; NL, 105 +/- 28 pg/ml).”

“Analyses of ion currents demonstrated that EST increased the density of I(Ca, L ) as compared with OVX (P <.05) while PROG decreased it (P <.05).”

“Additionally, 17beta-estradiol decreased the calcium current (i[Ca, L ]) to 76% (10 micromol/l) and 38% at 30 micromol/l.”

“3) There was an increase in oestradiol concentration from 17.1 +/- 3.0 pmol/l during the L period to 233.7 +/- 86.4 pmol/l during the F period.”

“ Oestradiol increased the dry weight of the islets of Langerhans and enhanced total incorporation of [3H] leucine into newly synthetized proteins during a glucose stimulation independently of the presence of the adrenal glands.”

“The effects were dose dependent; the half-maximal dose of insulin was about 2 X … and of estradiol was about 5 X 10(-11) M. Treatment with both insulin and estradiol increased … [3H]leucine by 45% compared to controls, incorporation of [3H]… by 65%, and total protein by 50%.”

“By 72 hr, transport of both proline and leucine was significantly decreased; incorporation of leucine into proteins and uridine into RNA was significantly reduced by 24 hr after injection of estradiol valerate.”

“At 2 h following the injection of 17β-estradiol into immature chicks, the rate of [3H]leucine incorporation into total nuclear protein of liver, after correction for the free leucine pool, was increased 3.6-fold over that of the controls.”