Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Estradiol and Isoflavones

supplement:

Isoflavones

Research Papers that Mention the Interaction

Mammographic density is not affected by soy or phytoestrogen products and recent in vitro work shows only a weakly proliferative effect of soy isoflavone on breast cancer cells and evidence that soy isoflavone blocks the proliferative effect of estradiol on these cells.
Menopause international  •  2012  |  View Paper
Isoflavone had a significant tendency to be negatively associated with estradiol in boys and to be positively associated with testosterone in girls.
American journal of epidemiology  •  2011  |  View Paper
The negative correlations observed between isoflavones and estradiol in women as a whole became no longer significant when we excluded women with ESR1 PvuII CC genotype, indicating that the correlations observed were due mainly to this group of women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology  •  2005  |  View Paper
However, isoflavones (at 10(-8) and above concentrations) were also antiestrogenic when combined with estradiol (E(2)) (P < 0.05).
The Journal of clinical endocrinology and metabolism  •  2002  |  View Paper
DISCUSSION These findings showed that long-term treatment with commercial isoflavones decreased total body weight gain and facilitated spatial memory performance in rats and this may be involved with the increase in estradiol levels as well as the increase in GABA and glutamate levels in PFC.
Nutritional neuroscience  •  2018  |  View Paper
Isoflavones circulate at concentrations that are 13,000-22,000-fold higher than plasma estradiol concentrations in early life.
The American journal of clinical nutrition  •  1998  |  View Paper
This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2017  |  View Paper
The purpose of this study was to investigate whether the acceleration of VO by IF (1) has a critical window, (2) is modified by IF exposure combined with 17beta-estradiol (E2), and (3) has any relation with gene expressions of estrogen-related receptors (ERRs).
Reproductive toxicology  •  2007  |  View Paper
An increase in mRNA for both genes was noted after estradiol treatment and with the highest dose of IFs.
Cancer research  •  2003  |  View Paper