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Last Updated: 6 months ago

Possible Interaction: Estradiol and Isoflavones

supplement:

Isoflavones

Research Papers that Mention the Interaction

Compared with the control diet, increased isoflavone consumption decreased urinary excretion of estradiol , estrone, estriol, and total estrogens, as well as excretion of the hypothesized genotoxic estrogen metabolites, 16alpha-hydroxyestrone, 4-hydroxyestrone, and 4-hydroxyestradiol.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology  •  1998  |  View Paper
Isoflavones circulate at concentrations that are 13,000-22,000-fold higher than plasma estradiol concentrations in early life.
The American journal of clinical nutrition  •  1998  |  View Paper
Mammographic density is not affected by soy or phytoestrogen products and recent in vitro work shows only a weakly proliferative effect of soy isoflavone on breast cancer cells and evidence that soy isoflavone blocks the proliferative effect of estradiol on these cells.
Menopause international  •  2012  |  View Paper
Isoflavone had a significant tendency to be negatively associated with estradiol in boys and to be positively associated with testosterone in girls.
American journal of epidemiology  •  2011  |  View Paper
The negative correlations observed between isoflavones and estradiol in women as a whole became no longer significant when we excluded women with ESR1 PvuII CC genotype, indicating that the correlations observed were due mainly to this group of women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology  •  2005  |  View Paper
However, isoflavones (at 10(-8) and above concentrations) were also antiestrogenic when combined with estradiol (E(2)) (P < 0.05).
The Journal of clinical endocrinology and metabolism  •  2002  |  View Paper
The purpose of this study was to investigate whether the acceleration of VO by IF (1) has a critical window, (2) is modified by IF exposure combined with 17beta-estradiol (E2), and (3) has any relation with gene expressions of estrogen-related receptors (ERRs).
Reproductive toxicology  •  2007  |  View Paper
An increase in mRNA for both genes was noted after estradiol treatment and with the highest dose of IFs.
Cancer research  •  2003  |  View Paper