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Possible Interaction: Estradiol and Indole-3-Carbinol

Research Papers that Mention the Interaction

Indole-3-carbinol affects the ratio of hydroxylation of estradiol ; changes in the ratios of urinary 2-hydroxylation and 16-hydroxylation of estradiol caused by indole-3-carbinol correlated well with clinical response.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery  •  1998  |  View Paper
This inhibition was partially reversed by the addition of indole-3-carbinol , a potent inducer of 2-hydroxylation of estradiol.
In vivo  •  2011  |  View Paper
Higher concentrations of I3C overcame the anti-apoptotic effect of estradiol.
Treatment with I3C resulted in loss of the survival protein Bcl-2, and estradiol partially reversed this effect.
Anticancer research  •  2004  |  View Paper
Both I3C and 2-OHE competed with estradiol for estrogen receptor binding.
Anticancer research  •  1999  |  View Paper
Additionally, I3C can reduce cervical dysplasia caused by estradiol in the normal mouse (3).
The Journal of nutrition  •  2006  |  View Paper
Estradiol reduced the percentage of these late-stage apoptotic cells in the cervical epithelium of transgenic, E2-treated mice, but this reduction was prevented by I3C.
The Journal of nutrition  •  2001  |  View Paper
The suggestion that ICZ can inhibit estrogen activity via induction of the cytochrome P450 monoxygenase system comes from studies showing that TCDD and I3C increase CYPlA2-catalyzed 2hydroxylation of estradiol and, as a consequence, decrease the estrogen response (7).
Journal of the National Cancer Institute  •  1994  |  View Paper
Linagliptin and/or I3C induced significant decrease in tissue TGF-β1, TNF-α, IL-10, plasma free testosterone, luteinizing hormone, progesterone, estradiol , FBG and insulin levels associated with significant improvement of insulin resistance whereas tissue Nrf2/HO-1 content and antioxidant enzymes were significantly increased compared to PCOS group.
Chemico-biological interactions  •  2017  |  View Paper
Biochemical … of I3C … estradiol 2-hydroxylation (nmol/mg protein) compared to rats treated without I3C [0.34 +/- 0.04 in group 2, 0.53 +/- 0.13 in … in group 4 versus 0.28 +/- 0.02 in group 1; P < 0.02, P < 0.003, and P < 0.001, respectively].
Cancer research  •  1994  |  View Paper