Possible Interaction: Estradiol and Hydroxyproline

“Treatment with … nM oestradiol-17beta of cell strains derived from eight young … (less than 50 years of age) increased hydroxyproline levels significantly [an average (2.2+/-0.1 S.E.M.)-fold increase], whereas cells … from nine older women (more than 50 years of age) were not significantly affected.”

“RESULTS The amount of hydroxyproline in the skin significantly (P = 0.012) increased from 11.8 to 16.3 micrograms (38%) during oestradiol treatment.”

“ RESULTS The amount of hydroxyproline in the skin significantly (P = 0.012) increased from 11.8 to 16.3 micrograms (38%) during oestradiol treatment.”

“In common with other estrogens, transdermal estradiol inhibits bone resorption, as evidenced by reduction in urinary excretion of calcium and hydroxyproline and other metabolic markers of bone resorption, and small increases in bone mineral density (BMD) in postmenopausal women receiving long term treatment.”

“The hydroxyproline levels were significantly lower in the rats treated with estradiol and progesterone.”

“The rats receiving 1 mug oestradiol per day had a significantly higher specific activity of hydroxyproline in bone compared to the normal and the castrated control rats.”

“In the rats treated with estradiol specific activity of hydroxyproline in both collagen and elastin declined more rapidly than in oil treated rats.”

“The wet weight and the dry, defatted weight of metaphyseal bone were increased by estradiol and the specific activity of hydroxyproline in collagen and proline in the noncollagenous protein was increased. ”

“The wet weight and the dry, defatted weight of metaphyseal bone were increased by estradiol and the specific activity of hydroxyproline in collagen and proline in the noncollagenous protein was increased.”