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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Estradiol
supplement:
Homocysteine
Research Papers that Mention the Interaction
“CONCLUSION The reduction in plasma homocysteine levels observed after 6 months' treatment with intranasal 17beta-estradiol may reflect an alteration in folate and Vitamin B12 homeostasis.”
“RESULTS … receiving intranasal 17beta-estradiol , mean (+/-….) plasma homocysteine level decreased significantly from pre-treatment values (from 16.68+/-4.33 to 14.15+/-1.18 nmol/ml, p=0.… the mean folate level increased (from 4.11+/-0.80 to 5.64+/-1.87 ng/ml, p=0.012).”
Intranasal 17beta-estradiol treatment and Vitamin B12, folate and homocysteine in menopause.“The mean change from baseline in homocysteine concentration by both treatments compared with placebo ( ET , -13%; EPT, -10%) was accompanied by a decrease in the concentration of vitamin B6 (ET, -25%; EPT, -38%) and albumin (ET, -7%; EPT, -11%).”
“LDL-C (-6%), apo B (-9%), triglyceride (-5%), and homocysteine (-11%) concentrations decreased with estradiol , whereas HDL-C (+14%) increased.”
“We also found slight negative but insignificant correlations of homocysteine levels with estradiol in both phases of the menstrual cycle.”
“We investigated whether 17-beta estradiol may prevent the accelerated rate of endothelial cell detachment and reduced cell viability in cultured endothelial cells challenged with Hcy.”
17-beta estradiol preserves endothelial cell viability in an in vitro model of homocysteine-induced oxidative stress.
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