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“CONCLUSION The reduction in plasma homocysteine levels observed after 6 months' treatment with intranasal 17beta-estradiol may reflect an alteration in folate and Vitamin B12 homeostasis.”
“RESULTS … receiving intranasal 17beta-estradiol , mean (+/-….) plasma homocysteine level decreased significantly from pre-treatment values (from 16.68+/-4.33 to 14.15+/-1.18 nmol/ml, p=0.… the mean folate level increased (from 4.11+/-0.80 to 5.64+/-1.87 ng/ml, p=0.012).”
“The mean change from baseline in homocysteine concentration by both treatments compared with placebo ( ET , -13%; EPT, -10%) was accompanied by a decrease in the concentration of vitamin B6 (ET, -25%; EPT, -38%) and albumin (ET, -7%; EPT, -11%).”
European journal of clinical investigation • 1999 | View Paper
“We investigated whether 17-beta estradiol may prevent the accelerated rate of endothelial cell detachment and reduced cell viability in cultured endothelial cells challenged with Hcy.”