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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Estradiol
supplement:
Glutathione
Research Papers that Mention the Interaction
“ Glutathione had less effect on the formation of 3H2O for the aromatic ring of estradiol than from that of the catechol estrogen where it increased the yield 6-fold.”
Peroxidase-catalyzed displacement of tritium from regiospecifically labeled estradiol and 2-hydroxyestradiol.“During the 6-OHDA induced PD, the level of antioxidant marker such as GSH , ROS and TRAP, found to be significantly modulated by the estradiol. ”
Mechanistic evaluation of neuroprotective effect of estradiol on rotenone and 6-OHDA induced Parkinson's disease.“ Estradiol prevents Hcy-induced endothelial cell injury by increasing the intracellular content of GSH.”
“The dose of estradiols required for motor neuron protection was greatly reduced by co-administration with glutathione.”
“ Estradiol (0.1-1.5 mM) produced a dose-dependent depletion of cellular reduced glutathione ( GSH ), whereas it did not alter the glutathione disulfide (GSSG) excretion into the medium.”
“In rat liver microsomes, estradiol (5-50 microM) significantly interacted with GSH only when an NADPH-regenerating system was incorporated into the medium.”
“ Glutathione promoted the loss of 3H from C-4 of either estradiol or 2-hydroxyestradiol but had less effect on this reaction at C-1 and inhibited it at C-6,7.”
“Ascorbic acid and glutathione inhibited covalent binding of estradiol to macromolecules in the in vitro microsomal system.”
“Treatment of gonadectomized rats with subcutaneous implants of oestradiol and of progesterone increased the rate of oxidation of GSH by about 100%.”
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